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Ultrasound-laccase pre-treatment enhances agarwood essential oil extraction and bioactivity.
Int J Biol Macromol
January 2025
Research Institute of Wood Industry of Chinese Academy of Forestry, 100091, Beijing, PR China. Electronic address:
Agarwood essential oil is prized for its elegant aroma and pharmacological properties; however, the traditional hydrodistillation method suffers from inefficiencies, constraining the industrial potential of agarwood. We proposed an ultrasonic-assisted laccase synergistic pretreatment technique that enhanced extraction throughput by 70.90 % compared to the traditional method by facilitating pore formation in agarwood and expediting the release of essential oil.
View Article and Find Full Text PDFPotassium Persulfate Promoted the One-Pot and Selective -Functionalization of Pyrazoles under Acidic Conditions.
ACS Omega
December 2024
SupraSelen Laboratory, Department of Chemistry, Universidade Federal Fluminense, Institute of Chemistry, Campus do Valonguinho, 24020-141 Niterói-RJ, Brazil.
Our research presents selective direct selenylation at the C-4 pyrazole ring using KSO as an oxidant under simple and mild conditions. This elegant synthesis involves the one-pot method under acidic conditions, thus minimizing reaction steps and waste generation. This innovative method allowed us to create a library of 4-selanylpyrazoles in good to excellent yields.
View Article and Find Full Text PDFPopulation-aware permutation-based significance thresholds for genome-wide association studies.
Bioinform Adv
October 2024
Technical University of Munich, TUM Campus Straubing for Biotechnology and Sustainability, Bioinformatics, 94315 Straubing, Germany.
Motivation: Permutation-based significance thresholds have been shown to be a robust alternative to classical Bonferroni significance thresholds in genome-wide association studies (GWAS) for skewed phenotype distributions. The recently published method permGWAS introduced a batch-wise approach to efficiently compute permutation-based GWAS. However, running multiple univariate tests in parallel leads to many repetitive computations and increased computational resources.
View Article and Find Full Text PDFDifferential and synergistic effects of right and left atrial ganglionated plexi ablation in patients undergoing cardioneuroablation: results from the ELEGANCE multicenter study.
J Interv Card Electrophysiol
December 2024
Arrhythmia Department, Teknon Heart Institute, Teknon Medical Center, Barcelona, Spain.
Background: Cardioneuroablation (CNA) treats reflex syncope by ablating ganglionated plexi (GPs) either confined to the right (RA) or left atrium (LA), or accessible from both. We assessed whether GP ablation in one atrium affects parasympathetic modulation in the other and how ablation sequence (RA then LA, or vice-versa) impacts efficacy.
Methods: Two propensity-matched groups of patients with reflex syncope or functional bradycardia were analyzed.
Bioresponsive Polymeric Nanoparticles: From Design, Targeted Therapy to Cancer Immunotherapy.
Biomacromolecules
January 2025
Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, PR China.
Bioresponsive polymeric nanoparticles (NPs) that are capable of delivering and releasing therapeutics and biotherapeutics to target sites have attracted vivid interest in cancer therapy and immunotherapy. In contrast to enthusiastic evolution in the academic world, the clinical translation of these smart systems is scarce, partly due to concerns about safety, stability, complexity, and scalability. The moderate targetability, responsivity, and benefits are other concerns.
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