AI Article Synopsis
- Bioindustry is expanding to create diverse food, chemical, and pharmaceutical products, necessitating fast development of specialized cell factories and bioprocesses.
- Microfluidic tools, along with synthetic biology and metabolic modeling, are being used to enhance the speed and efficiency of this development process.
- Recent advancements include devices for DNA assembly, high throughput screening of cell factories, and micron-scale bioreactors, all aimed at improving the biotechnological engineering cycle through increased throughput, parallelization, and automation.
Article Abstract
Bioindustry is expanding to an increasing variety of food, chemical and pharmaceutical products, each requiring rapid development of a dedicated cell factory and bioprocess. Microfluidic tools are, together with tools from synthetic biology and metabolic modeling, being employed in cell factory and bioprocess development to speed up development and address new products. Recent examples of microfluidics for bioprocess development range from integrated devices for DNA assembly and transformation, to high throughput screening of cell factory libraries, and micron scale bioreactors for process optimization. These improvements act to improve the biotechnological engineering cycle with tools for building, testing and evaluating cell factories and bioprocesses by increasing throughput, parallelization and automation.
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| http://dx.doi.org/10.1016/j.copbio.2018.08.011 | DOI Listing |
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