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Optical Coherence Tomography Angiography in Patients With the Boston Keratoprosthesis Type 1.
Cornea
January 2025
Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Purpose: To report on optical coherence tomography angiography (OCTA) in patients with a type 1 Boston keratoprosthesis (KPro) and determine its feasibility through assessment of imaging artifacts.
Methods: KPro and non-KPro subjects were matched for age, gender, and glaucoma diagnosis. OCTA images of the peripapillary optic nerve were obtained, reviewed by 2 readers masked to the diagnosis for artifacts and usability, and used for microvascular measurements.
Comparison of I-gel and Baska mask in elective surgery: a meta-analysis.
BMJ Open
December 2024
Department of Intensive Care, Cangzhou Central Hospital, Cangzhou, China
Objective: The supraglottic airway device is a viable alternative to tracheal intubation for elective surgery. To conduct a comparative analysis of the advantages and disadvantages associated with use of the Baska mask and I-gel across various dimensions.
Design: A comprehensive search was conducted across PubMed, Embase, Cochrane Library, Web of Science, and other relevant databases to identify randomised controlled trials (RCTs) involving patients who used the Baska mask and I-gel.
Frailism: a scoping review exploring discrimination against people living with frailty.
Lancet Healthy Longev
December 2024
University of the West of England, School of Health and Social Wellbeing, Bristol, UK; Research in Emergency Care, Avon Collaborative Hub (REACH), Bristol, UK.
People living with frailty can experience discrimination, but unlike the characteristics of age and disability, frailty is not protected by law. Frailty is a clinical syndrome associated with ageing in which health deficits increase a person's vulnerability to illness, disability, and death. This scoping review, conducted by a team of methodologists, clinicians, lawyers, and patients, aimed to investigate the extent of discrimination against people living with frailty described in health-care literature.
View Article and Find Full Text PDFReal-World Evaluation of i-gel Introduction on Intraoperative Airway-Related Safety Events: A Retrospective Cohort Study From a New England Hospital Network.
Anesth Analg
February 2025
Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Background: Several health care networks have fully adopted second-generation supraglottic airway (SGA) i-gel. Real-world evidence of enhanced patient safety after such practice change is lacking. We hypothesized that the implementation of i-gel compared to the previous LMA®-Unique™ would be associated with a lower risk of airway-related safety events.
View Article and Find Full Text PDFCANBERRA: A Phase II Randomized Clinical Trial to Test the Therapeutic Potential of Oral Vicasinabin in Diabetic Retinopathy.
Ophthalmol Sci
November 2024
Roche Pharmaceutical Research and Early Development, Translational Medicine Ophthalmology, Roche Innovation Center, Basel, Switzerland.
Objective: Nonproliferative diabetic retinopathy (NPDR) is a progressive disease that can lead to blindness. Current therapies for NPDR are invasive and not extensively used or accessible until the disease progresses, pointing to the need for an early noninvasive treatment. The objective of CANBERRA was to assess the safety, tolerability, and efficacy of oral administration of vicasinabin (RG7774) on the severity of diabetic retinopathy (DR) in participants with moderately severe to severe NPDR and good vision.
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