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Similar Publications

Intraoperative optical coherence tomography (iOCT) has been applied and studied in a variety of vitreoretinal surgeries for its feasibility, safety, and outcomes for years. Common scenarios include membrane peeling procedures, retinal detachments, choroidal-retinal biopsies, Argus implants, and subretinal injections. iOCT offers the surgeon a better understanding of the retinal microarchitectural changes and timely intraoperative feedback, directing a future view of precision surgery.

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Purpose: Avacopan is a novel C5a receptor inhibitor which was recently licensed for treatment of severe granulomatosis with polyangiitis (GPA) in the European Union and the United Kingdom. To the best of our knowledge, this is the first described case on initial ophthalmic outcomes in a patient with severe GPA and concurrent refractory scleritis treated with avacopan.

Case Description: We present a case of de novo scleritis in a 77-year-old male with a background of retinitis pigmentosa with Argus II implant in situ.

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Objective: To quantitatively evaluate visual evoked potentials (VEPs) in prosthetic vision and simulated visual reduction.

Methods And Analysis: Four blind patients implanted with the Argus II retinal prosthesis and seven sighted controls participated. VEPs were recorded with pattern-reversal stimuli (2 cycles of a horizontal square wave grating, 0.

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Article Synopsis
  • The Argus II retinal prosthesis helps restore vision to late-blind patients, and its effects on brain structure are being studied to understand changes in cortical thickness.
  • A comparison of cortical thickness showed that Argus II patients had thicker visual cortex areas than blind patients, with longer usage linked to increased thickness in these regions.
  • Case studies indicate that extended use of the Argus II device may lead to rejuvenation of visual cortical areas, suggesting potential for reversing brain atrophy caused by late blindness.
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Retinal implants use electrical stimulation to elicit perceived flashes of light ('phosphenes'). Single-electrode phosphene shape has been shown to vary systematically with stimulus parameters and the retinal location of the stimulating electrode, due to incidental activation of passing nerve fiber bundles. However, this knowledge has yet to be extended to paired-electrode stimulation.

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