Background: Consumption of added sugars (AS) and sugar-sweetened beverages (SSB) may adversely affect adolescents' weight and cardiovascular disease risk. Reliance on self-reported dietary assessment methods is a common research limitation, which could be overcome by dietary intake biomarkers.
Aim: The investigation was a proof-of-concept study to evaluate the proposed carbon isotope ratio (δC) biomarker of AS intake in adolescents, using a controlled feeding design.
Methods: Participants ( = 33, age 15.3 years, 53% female) underwent two seven-day controlled feeding periods in a randomly assigned order. Diets were matched in composition except for AS content (5% or 25% of total energy). Fasting fingerstick blood samples were collected daily during each diet period.
Results: Fingerstick δC values changed from day 1 to 8 by -0.05 ± 0.071‰ on 5% AS, and +0.03 ± 0.083‰ on 25% AS ( ≤ 0.001). Reliability was demonstrated between day 7 and 8 δC values on the 5% (ICC = 0.996 ≤ 0.001) and 25% (ICC = 0.997, ≤ 0.001) AS diets.
Conclusions: Larger scale investigations are warranted to determine if this technique could be applied to population-level research in order to help assess the effectiveness of interventions aimed at reducing the consumption of AS or SSB intake.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817487 | PMC |
| http://dx.doi.org/10.1177/0260106018799522 | DOI Listing |
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