AI Article Synopsis
- Zinc deficiency is linked to anemia in rats, mice, and humans, and zinc supplementation can enhance hemoglobin production.
- Previous research shows zinc aids red blood cell production in fish, but its effects in rats were unclear until this study.
- The experiment revealed that zinc injections significantly boosted red blood cell levels in anemic rats, with higher doses leading to greater increases in RBC formation.
Article Abstract
In rats, mice, and humans, it is known that zinc deficiency may be related to anemia, and zinc supplementation influences hemoglobin production. Our previous studies indicate that in fish, zinc supplementation stimulates red blood cell (RBC) formation (erythropoiesis). However, it is not clear whether the mechanism of zinc-induced erythropoiesis stimulation in fish also occurs in rats. We induced anemia in rats using phenylhydrazine (PHZ) and injected either saline or ZnSO₄ solution. We found that an appropriate amount of zinc stimulated erythropoiesis in the PHZ-induced anemic rats. The effects of ZnSO₄ injection were dose-dependent. When the concentration of ZnSO₄ was higher than 2.8 mg zinc/kg body weight, the RBC level of the anemic rats increased from 60 ± 7% to 88 ± 10% that of the normal rats in two days. Rat bone marrow cells with or without ZnCl₂ supplementation were cultured in suspension in vitro. In the cell culture when the zinc concentration was at 0.3 mM, a 1.6-fold proliferation of nascent immature reticulocytes (new RBCs) was observed after one day. In the rat blood, zinc was combined with serum transferrin to induce erythropoiesis. The stimulation of RBC formation by zinc appears to be common among different animals.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165144 | PMC |
| http://dx.doi.org/10.3390/ijms19092824 | DOI Listing |
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