Two new alkaloids, fumigatosides E () and F (), and a new natural product, 3, 7-diketo-cephalosporin P₁ () along with five known compounds (⁻, , ) were isolated from deep-sea derived fungal SCSIO 41012. Their structures were determined by extensive spectroscopic data analysis, including 1D, 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS), and comparison between the calculated and experimental electronic circular dichroism (ECD) spectra. In addition, all compounds were tested for antibacterial and antifungal inhibitory activities. Compound showed significant antifungal activity against f. sp. with MIC at 1.56 µg/mL. Compound exhibited significant higher activity against (16,339 and 29,213) with MIC values of 1.56 and 0.78 µg/mL, respectively, and compound exhibited significant activity against ATCC 19606 with a MIC value of 6.25 µg/mL.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225233 | PMC |
| http://dx.doi.org/10.3390/molecules23092379 | DOI Listing |
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