We study the non-equilibrium coarsening dynamics of a binary liquid solvent around a colloidal particle in the presence of a time-dependent temperature gradient that emerges after a temperature quench of a suitable coated colloid surface. The solvent is maintained at its critical concentration and the colloid is fixed in space. The coarsening patterns near the surface are shown to be strongly dependent on the colloid surface adsorption properties and on the temperature evolution. The temperature gradient alters the morphology of the binary solvent near the surface of the colloid as compared to the coarsening proceeding at a constant temperature everywhere. We also present results for the evolution of coarsening in thin films with confining surfaces preferring one species of the binary liquid mixture over the other. Confinement leads to a faster phase segregation process and formation of a bridge connecting the colloid and both confining walls.
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http://dx.doi.org/10.1039/c8sm01258j | DOI Listing |
J Phys Chem B
January 2025
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Reline, which is composed of choline chloride and urea in a molar ratio of 1:2, is the first and most extensively studied deep eutectic solvent (DES). In certain applications, reline is blended with organic solvents, dimethyl sulfoxide (DMSO) in most cases, to gain improved properties. Therefore, it is crucial to have a profound understanding of the impact of DMSO on the dynamics and structures of the species in the binary mixtures.
View Article and Find Full Text PDFSurface active ionic liquids (SAILs), offer potential advantages for pharmaceutical applications. Given the low permeability of gabapentin, an antiepileptic drug, in the gastrointestinal tract as classified by the Biopharmaceutics Classification Systems (BCS), understanding the micellization behavior of SAILs is essential for developing effective drug delivery systems to improve gabapentin bioavailability. This study explores the micellization and thermophysical behavior of SAILs (2-hydroxyethyl)ammonium laurate [2-HEA][Lau], bis(2-hydroxyethyl)ammonium laurate [BHEA][Lau], and tris(2-hydroxyethyl)ammonium laurate [THEA][Lau] in the presence of aqueous gabapentin solution at varied temperatures through COSMO analysis, electrical conductivity and surface tension measurements.
View Article and Find Full Text PDFJ Pharm Biomed Anal
January 2025
Sabanci University Nanotechnology Research and Application Center (SUNUM), Istanbul 34956, Turkey.
This study aimed to determine the chromatographic retention and dissociation/protonation constant (pK) values of lapatinib and tamoxifen, key drugs used in metastatic breast cancer treatment, at 37°C using both conventional and green high-performance liquid chromatography (HPLC) methods. Qualitative analysis was conducted on an XTerra C18 column (250 ×4.6 mm I.
View Article and Find Full Text PDFInt J Thermophys
January 2024
Applied Chemicals and Materials Division, National Institute of Standards and Technology, Boulder, CO 80305, USA.
Sound speed data measured using a dual-path pulse-echo instrument are reported for pure -1,2-dichloroethene (R-1130(E)) and an azeotropic blend of -1,1,1,4,4,4-hexafluorobutene (R-1336mzz(Z)) and R-1130(E) with a composition of 74.8 mass % R-1336mzz(Z) with the balance being R-1130(E). The azeotropic blend of R-1336mzz(Z)/1130(E) is classified as R-514A in ANSI/ASHRAE standard 34.
View Article and Find Full Text PDFJ Phys Chem B
January 2025
Molecular Modeling Laboratory, Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
It is widely believed that the aggregation of amyloid β (Aβ) peptides into soluble oligomers is the root cause behind Alzheimer's disease. In this study, we have performed room-temperature molecular dynamics (MD) simulations of aggregated Aβ oligomers of different sizes (pentamer (O(5)), decamer (O(10)), and hexadecamer (O(16))) in binary aqueous solutions containing 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF]) ionic liquid (IL). Investigations have been carried out to obtain a microscopic understanding of the effects of the IL on the dynamic environment around the exterior surfaces and within the confined nanocores of the oligomers.
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