AI Article Synopsis

  • This study aimed to analyze the clinical features of elderly patients with hemorrhagic gastroduodenal ulcers who are on low-dose aspirin (LDA) therapy.
  • Researchers evaluated 1,105 patients, comparing factors like hospital stay duration, hemoglobin levels, blood transfusion rates, and severity of cases across different age groups and treatment regimens.
  • Findings indicated that elderly patients on LDA combination therapy faced worse outcomes, with higher rates of blood transfusions, hemoglobin decreases, and longer hospital stays, while LDA monotherapy did not show significant differences between age groups.

Article Abstract

Aim: To determine the clinical characteristics of elderly patients of hemorrhagic gastroduodenal ulcer on low-dose aspirin (LDA) therapy.

Methods: A total of 1105 patients with hemorrhagic gastroduodenal ulcer treated in our hospital between January 2000 and March 2016 were grouped by age and drugs used, and these groups were compared in several factors. These groups were compared in terms of length of hospital stay, presence/absence of hemoglobin (Hb) decrease, presence/absence of blood transfusion, Forrest I, percentage of infection, presence/absence of underlying disease, and percentage of severe cases.

Results: The percentage of blood transfusion (62.6% 47.7 %, < 0.001), Hb decrease (53.8% 40.8%, < 0.001), and the length of hospital stay (23.5 d 16.7 d, < 0.001) were significantly greater in those on drug therapy. The percentage of blood transfusion (65.3% 47.8%, < 0.001), Hb decrease (54.2% 42.1%, < 0.001), and length of hospital stay (23.3 d 17.5 d, < 0.001) were significantly greater in the elderly. In comparison with the LDA monotherapy group, the percentage of severe cases was significantly higher in the LDA combination therapy group when elderly patients were concerned (16.1% 34.0%, = 0.030). Meanwhile, among those on LDA monotherapy, there was no significant difference between elderly and non-elderly (16.1% 16.0%, = 0.985).

Conclusion: A combination of LDA with antithrombotic drugs or non-steroidal anti-inflammatory drugs (NSAIDs) contributes to aggravation. And advanced age is not an aggravating factor when LDA monotherapy is used.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141337PMC
http://dx.doi.org/10.3748/wjg.v24.i34.3908DOI Listing

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