[This corrects the article DOI: 10.1371/journal.pone.0167573.].

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143258PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204536PLOS

Publication Analysis

Top Keywords

correction mice
4
mice hemizygous
4
hemizygous pathogenic
4
pathogenic mitofusin-2
4
mitofusin-2 allele
4
allele exhibit
4
exhibit hind
4
hind limb/foot
4
limb/foot gait
4
gait deficits
4

Similar Publications

Correction: Yu et al. The Role of circTmeff-1 in Morphine Addiction Memory of Mice. 2023, , 1985.

Cells

December 2024

Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, College of Forensic Medicine, Hebei Medical University, Chinese Academy of Medical Sciences, Shijiazhuang 050000, China.

In the original publication [...

View Article and Find Full Text PDF

The genetic quality of laboratory mice may have a direct impact on the results of research. Therefore, it is essential to improve genetic monitoring methods to guarantee research quality. However, few current methods boast high efficiency, high throughput, low cost, and general applicability at the same time.

View Article and Find Full Text PDF

In vivo genome editing holds great therapeutic potential for treating monogenic diseases by enabling precise gene correction or addition. However, improving the efficiency of delivery systems remains a key challenge. In this study, we investigated the use of lipid nanoparticles (LNPs) for in vivo knock-in of ectopic DNA.

View Article and Find Full Text PDF

Mucopolysaccharidosis type I (MPS I) is a metabolic disorder characterized by a deficiency in α-l-iduronidase (IDUA), leading to impaired glycosaminoglycan degradation. Current approved treatments seek to restore IDUA levels via enzyme replacement therapy (ERT) and/or hematopoietic stem cell transplantation (HSCT). The effectiveness of these treatment strategies in preventing neurodegeneration is limited due to the inability of ERT to penetrate the blood-brain barrier (BBB) and HSCT's limited CNS reconstitution of IDUA levels.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!