AI Article Synopsis
- Congenital Zika virus syndrome leads to various neurological issues in infants infected with the virus during pregnancy, but effects on children without visible birth defects are less clear.
- A case-control study explored the link between maternal Zika virus infection and congenital defects, while also evaluating early childhood development of controls born without birth defects.
- The results indicated a connection between congenital defects and maternal Zika virus infections, but there was no significant evidence of developmental delays in early childhood, suggesting the need for more extensive future studies.
Article Abstract
Congenital Zika virus syndrome consists of a large spectrum of neurologic abnormalities seen in infants infected with Zika virus in utero. However, little is known about the effects of Zika virus intrauterine infection on the neurocognitive development of children born without birth defects. Using a case-control study design, we investigated the temporal association of a cluster of congenital defects with Zika virus infection. In a nested study, we also assessed the early childhood development of children recruited in the initial study as controls who were born without known birth defects,. We found evidence for an association of congenital defects with both maternal Zika virus seropositivity (time of infection unknown) and symptomatic Zika virus infection during pregnancy. Although the early childhood development assessment found no excess burden of developmental delay associated with maternal Zika virus infection, larger, longer-term studies are needed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154169 | PMC |
| http://dx.doi.org/10.3201/eid2410.172079 | DOI Listing |
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