AI Article Synopsis

  • Verruciform xanthoma (VX) is a wart-like mucosal lesion, characterized by its histological features of papillary epithelium and foam cells in the lamina propria, making it tricky to diagnose without a biopsy.
  • A 62-year-old man presented with a persistent white lesion in his posterior mandibular gingiva, which was initially overlooked due to lack of symptoms but later required comprehensive examination and biopsy after the lesion changed in appearance.
  • The final diagnosis of VX was confirmed through histopathological examination, highlighting the challenges of preoperative diagnosis, as VX can mimic other benign conditions and is often mistaken for papilloma.

Article Abstract

Verruciform xanthoma (VX), a papillary or wart-like lesion of the mucosa, is histopathologically characterized by papillary projection of the epithelium and an aggregation of foam cells in the lamina propria. Here, we describe a case of VX in the posterior mandibular gingiva, initially suspected to be a benign lesion based on clinical findings and cytology prior to an excisional biopsy. The patient was a 62-year-old man who had visited a local dentist approximately 1 year earlier, presenting with a white lesion in the left posterior mandibular gingiva that resisted removal by scraping. The lesion was left untreated as there were no subjective symptoms. Thereafter, the surface of the lesion roughened and the patient was referred to our department for a comprehensive examination. A circumscribed, granular mass, 15-mm in diameter, with a red and white surface was observed in the left posterior mandibular buccal gingiva. Exfoliative cytology was performed. The diagnosis was a class III lesion. Excisional biopsy was performed under local anesthesia. Histopathological examination led to a diagnosis of VX. At 1 year postoperatively, the patient is making satisfactory progress without recurrence. Verruciform xanthoma is difficult to diagnose preoperatively, and is commonly resected under a clinical diagnosis of papilloma or benign tumor. A benign lesion was also initially suspected in the present case and cytological analysis performed to confirm absence of malignancy. The lesion could not be diagnosed as VX preoperatively. Verruciform xanthoma can be over-diagnosed based solely on cytological examination because it often involves cellular atypia reflecting its characteristic extension of rete pegs and keratinization of surface cells, indicating the need for care in arriving at a definitive diagnosis.

Download full-text PDF

Source
http://dx.doi.org/10.2209/tdcpublication.2017-0034DOI Listing

Publication Analysis

Top Keywords

verruciform xanthoma
16
posterior mandibular
12
lesion
8
mandibular gingiva
8
initially suspected
8
benign lesion
8
excisional biopsy
8
lesion left
8
left posterior
8
diagnosis
5

Similar Publications

Oral Verruciform Xanthoma of the Lower Lip: A Rare Entity.

Cureus

November 2024

Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.

Article Synopsis
  • Oral verruciform xanthoma (OVX) is a rare, benign oral lesion that can resemble other common growths and has only a few documented cases.
  • It typically appears in areas like the masticatory mucosa, with its exact cause still uncertain, but it's thought to arise from monocyte/macrophage lineage.
  • In a reported case, a 20-year-old male had a keratotic growth on his lower lip that was diagnosed as OVX through histopathology and immunohistochemistry; it was successfully surgically excised with no recurrence afterward.
View Article and Find Full Text PDF

Verruciform xanthomas are rare lesions affecting 0.025-0.5% of the population.

View Article and Find Full Text PDF

[Not Available].

Swiss Dent J

June 2024

Klinik für Oral Health & Medicine, Universitäres Zentrum für Zahnmedizin Basel UZB, Uni-versität Basel, Schweiz.

Article Synopsis
  • * Its exact cause is unknown, and while it can occur in healthy people, it has also been seen in those with autoimmune conditions or chronic graft-versus-host disease (GvHD).
  • * The recommended treatment is to surgically remove the lesion, as demonstrated in a case involving a successful excision from a 56-year-old patient with GvHD after stem cell transplantation for Non-Hodgkin lymphoma.
View Article and Find Full Text PDF
Article Synopsis
  • The text discusses a rare case of verruciform xanthoma of the penis in a male patient who also has genital lichen sclerosus.
  • This is only the second documented case of this particular condition.
  • The authors recommend that when diagnosing verruciform xanthoma, healthcare providers should closely check for signs of lichen sclerosus, as these signs can be subtle.
View Article and Find Full Text PDF

Oral verruciform xanthomas mimicking potentially malignant disorders.

J Clin Exp Dent

April 2024

DDS, MSc, PhD. Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.

Article Synopsis
  • Verruciform xanthoma is a rare reactive lesion that typically appears in the skin but can also occur in the oral cavity, where it may be mistaken for leukoplakia.
  • The text describes two cases of 30-year-old individuals with white plaques on the tongue and floor of the mouth, which were confirmed to be oral verruciform xanthomas through histopathological analysis.
  • It's important for dental professionals to consider verruciform xanthoma in their differential diagnosis for potential oral cancer since it can appear in high-risk areas, with histopathological analysis being the most reliable method for diagnosis.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!