Insoluble liquids show layers such as water and oil. The detection of the exact interface locations and the level changes for layered liquids are of paramount importance for chemistry purifications, liquid storage in reservoirs, oil transportation, and chemical engineering. However, accurately measuring liquid layers is challenging. This paper introduces a multi-parameter sensing device based on a long-period fiber grating (LPFG) sensor simultaneously detecting boundary and level changes of layered liquids. Laboratory experiments demonstrated that the sensor device would respond to the liquid interface change as a sharp and sudden resonant wavelength change, while it would show a gradual and steady resonant wavelength change to the level changes of layered liquids. The lab experiments also showed that the sensor device has a higher sensitivity when a higher LPFG cladding mode is used.
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http://dx.doi.org/10.3390/s18093094 | DOI Listing |
J Biomol Struct Dyn
March 2025
School of Mechatronic Engineering and automation, Shanghai University, Shanghai, China.
Prediction of protein-ligand interactions is critical for drug discovery and repositioning. Traditional prediction methods are computationally intensive and limited in modeling structural changes. In contrast, data-driven deep learning methods significantly reduce computational costs and offer a more efficient approach for drug discovery.
View Article and Find Full Text PDFJAMA Cardiol
March 2025
Department of Cardiovascular Medicine and Section on Geriatrics and Gerontology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Importance: Excess body fat plays a pivotal role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). HU6 is a novel, controlled metabolic accelerator that enhances mitochondrial uncoupling resulting in increased metabolism and fat-specific weight loss.
Objective: To assess efficacy and safety of HU6 in reducing body weight, improving peak volume of oxygen consumption (VO2) and body composition among patients with obesity-related HFpEF.
JAMA Netw Open
March 2025
Department of Cardiovascular Medicine, St Luke's International Hospital, Tokyo, Japan.
Importance: Despite growing criticism of alcohol consumption due to its overall health risks, it remains unknown how changes in alcohol consumption, particularly cessation, affect lipid profiles outside of intense interventions.
Objective: To clarify the association of alcohol initiation and cessation with subsequent changes in low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C).
Design, Setting, And Participants: This cohort study included individuals undergoing annual checkups at a center for preventive medicine in Tokyo, Japan, from October 2012 to October 2022.
Am J Orthod Dentofacial Orthop
March 2025
Piracicaba Dental School, Orthodontics Department, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil. Electronic address:
Introduction: This longitudinal study assessed the intermaxillary and intraarch relationships from mixed to permanent dentitions during a 4-year follow-up.
Methods: The sample comprised 352 children evaluated for crowding, midline maxillary diastema, anterior spacing, overjet, overbite, and sagittal and transverse relationships in mixed (T1) and permanent (T2) dentition. Data between different time points were compared using McNemar and Bowker symmetry tests, with a significance level of 5%.
Adv Mater
March 2025
Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN, 46556, USA.
Programmable on-chip terahertz (THz) topological photonic devices are poised to address the rising need for high-capacity data systems, offering broad bandwidth, minimal loss, and reconfigurability. However, current THz topological chips rely on volatile tuning mechanisms that require continuous power to function. Here, a nonvolatile, programmable THz topological silicon chip is demonstrated that integrates a waveguide-cavity coupled system with phase-change material, GeSbTe (GST), enabling persistent and efficient functionality without constant power input.
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