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Pros and cons of sub-specialisation in orthopaedics and traumatology-Is the general orthopaedic and trauma surgeon a relic of the past?
Knee Surg Sports Traumatol Arthrosc
December 2024
Center of Orthopaedics and Traumatology, Brandenburg Medical School, University Hospital Brandenburg/Havel, Brandenburg an der Havel, Germany.
The evolution of orthopaedics has witnessed a pronounced shift from generalist practice to subspecialisation, a trend that has fundamentally reshaped the field over the past century. Originally, orthopaedic surgeons were trained to address a broad spectrum of musculoskeletal conditions. However, increasing complexity and specialization in knowledge have driven a progressive narrowing of focus within orthopaedics.
View Article and Find Full Text PDFPathways and enhanced evaluation system for green low-carbon development across diverse Chinese regions.
Front Public Health
December 2024
School of Public Administration, North China University of Water Resources and Electric Power, Zhengzhou, China.
Background: Rapid economic growth in China has led to significant resource and environmental challenges, particularly in less economically developed regions. This study aims to identify effective strategies for achieving green, low-carbon development in these regions during the economic transition.
Methods: We employed the Fuzzy-Set Qualitative Comparative Analysis (fsQCA) method to scrutinize the impact of economic, demographic, industrial, and technological factors on low-carbon development across a selection of Chinese provinces, including Qinghai, Hunan, Beijing, Shanghai, Tianjin, Hainan, and Chongqing.
Reflections on the Health System Impact Fellowship and the Future of Embedded Research Comment on "Early Career Outcomes of Embedded Research Fellows: An Analysis of the Health System Impact Fellowship Program".
Int J Health Policy Manag
December 2024
Autism Alliance of Canada and Department of Pediatrics, Faculty of Medicine & Dentistry, College of Health Sciences, University of Alberta, Edmonton, AB, Canada.
The Health System Impact (HSI) Fellowship program in Canada offers a transformative approach to health services and policy research (HSPR) training, preparing PhD graduates for diverse career pathways and leadership roles within learning health systems. This commentary builds on Kasaai and colleagues' evaluation of the HSI Fellowship to discuss the diverse career paths of alumni and highlight the multifaceted benefits of the program. Further, we emphasize the need for future research and knowledge mobilization to better understand and evaluate embedded research roles.
View Article and Find Full Text PDFSynthesis and multifaceted evaluation of novel AgCZ nanocomposite for targeted anti-angiogenic cancer therapy.
Sci Rep
November 2024
Department of pharmacy, Faculty of medicine and health science, Almahweet University, Almahweet, 6803, Yemen.
Angiogenesis is the formation of blood vessels from the existing vasculature, which is important in the tumor growth where the metastatic spread, of cancer cells depends on an adequate supply of oxygen and nutrients and the removal of waste products. Targeting angiogenesis has emerged as a promising therapeutic strategy for cancer treatment. This study presents the synthesis and evaluation of a novel Ag-CeO-ZnO (AgCZ) nanocomposite designed to specifically inhibit angiogenesis for effective cancer therapy.
View Article and Find Full Text PDFCytochrome and cancer cell metabolism: A new perspective.
Saudi Pharm J
December 2024
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Almajmaah-11952, Saudi Arabia.
Cytochrome is a vital electron carrier in the mitochondrial respiratory chain. When the outer membrane of mitochondria becomes permeable, cytochrome is discharged into the cytoplasm, where it initiates the intrinsic apoptosis pathway. The complex interaction between cytochrome and apoptosis protease-activating factor-1 (Apaf-1) leads to the formation of the apoptosome and activation of a cascade of caspases, highlighting the critical role of cytochrome in controlling cell death mechanisms.
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