Remarkable Changes of the Acidity of Bound Nitroxyl (HNO) in the [Ru(Me[9]aneN)(L)(NO)] Family ( n = 1-3). Systematic Structural and Chemical Exploration and Bioinorganic Chemistry Implications.

Inorg Chem

Departamento de Química Inorgánica, Analítica y Química Física, Facultad de Ciencias Exactas y Naturales, and INQUIMAE , Universidad de Buenos Aires, CONICET , Pabellón 2, 3er piso, Ciudad Universitaria, C1428EHA Ciudad Autónoma de Buenos Aires , Argentina.

Published: October 2018

This work demonstrates that the acidity of nitroxyl (HNO) coordinated to a metal core is significantly influenced by its coordination environment. The possibility that NO complexes may be the predominant species in physiological environments has implications in bioinorganic chemistry and biochemistry. This (apparently simple) result pushed us to delve into the basic aspects of HNO coordination chemistry. A series of three closely related {RuNO} complexes have been prepared and structurally characterized, namely [Ru(Me[9]aneN)(L)(NO)], with L = 2,2'-bipyridine, 4,4'-dimethoxy-2,2'-bipyridine, and 2,2'-bipyrimidine. These species have also been thoroughly studied in solution, allowing for a systematic exploration of their electrochemical properties in a wide pH range, thus granting access and characterization of the elusive {RuNO} systems. Modulation of the electronic density in the {RuNO} fragment introduced by changing the bidentate coligand L produced only subtle structural modifications but affected dramatically other properties, most noticeably the redox potentials of the {RuNO} couples and the acidity of bound HNO, which spans over a range of almost three pH units. Controlling the acidity of coordinated HNO by the rational design of coordination compounds is of fundamental relevancy in the field of inorganic chemistry and also fuels the growing interest of the community in understanding the role that different HNO-derived species can play in biological systems.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.inorgchem.8b01958DOI Listing

Publication Analysis

Top Keywords

acidity bound
8
nitroxyl hno
8
bioinorganic chemistry
8
hno
5
remarkable changes
4
acidity
4
changes acidity
4
bound nitroxyl
4
hno [rume[9]anenlno]
4
[rume[9]anenlno] family
4

Similar Publications

Characterization of insulin and bile acid complexes in liposome by different mass spectrometry techniques.

Anal Bioanal Chem

January 2025

Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.

Insulin bound with ligand molecules can improve its bioavailability in oral formulations. In this work, the interactions between insulin and bile acids of taurocholic acid (TCA) and glycocholic acid (GCA) are characterized using different mass spectrometry (MS) methods. Electrospray (ESI)-MS analysis revealed that GCA and TCA could interact with insulin individually or together through non-covalent bonds, and the products included mGCA-insulin, nTCA-insulin, and mGCA-nTCA-insulin complexes.

View Article and Find Full Text PDF

A conceptual mechanistic model of amino acid fluxes in the small intestine, taking the example of pig.

Animal

December 2024

PEGASE, INRAE, Institut Agro, 35590 Saint Gilles, France. Electronic address:

During digestion, almost 50% of absorbed essential amino acids (AAs) are metabolised by intestinal tissue, thus not appearing directly in the portal vein. This value, which is referred to as first-pass metabolism, seems high in relation to the overall efficiency of AA use considered in growth models. Experimental studies of first-pass metabolism are complicated due to the presence of numerous metabolic fluxes in the intestine and to the dynamics of digestion and absorption.

View Article and Find Full Text PDF

2-arachnadoyl glycerol (2-AG) is one of the most common endocannabinoid molecules with anti-proliferative, cytotoxic, and pro-proliferative effects on different types of tumors. Typically, it induces cell death via cannabinoid receptor 1/2 (CB1/CB2)-linked ceramide production. In breast cancer, ceramide is counterbalanced by the sphingosine-1-phosphate, and thus the mechanisms of 2-AG influence on proliferation are poorly understood.

View Article and Find Full Text PDF

Molecular Docking Studies and In Vitro Activity of Pancreatic Lipase Inhibitors from Yak Milk Cheese.

Int J Mol Sci

January 2025

Functional Dairy Products Engineering Laboratory of Gansu Province, College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China.

Pancreatic lipase serves as a primary trigger for hyperlipidemia and is also a crucial target in the inhibition of hypercholesterolemia. By synthesizing anti-hypercholesterolemic drugs such as atorvastatin, which are used to treat hypercholesterolemia, there were some side effects associated with the long-term use of statins. Based on this idea, in the present study, we identified peptides that inhibited PL by virtual screening and in vitro activity assays.

View Article and Find Full Text PDF

Transketolase promotes osteosarcoma progression through the YY1-PAK4 axis.

FEBS J

January 2025

Department of Orthopedics, Wuhan Hospital of Traditional Chinese and Western Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Osteosarcoma, a malignant bone tumor that occurs in adolescents, proliferates and is prone to pulmonary metastasis. Osteosarcoma is characterized by high genotypic heterogeneity, making it difficult to identify reliable anti-osteosarcoma targets. The genotype of osteosarcoma may be highly dynamic, but its high dependence on energy remains constant.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!