An indole diterpenoid isolated from the fungus sp. and its antimicrobial activity.

One new indole diterpenoid, drechmerin I (), was isolated from the fermentation broth of sp. isolated from the root of . Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I () was assayed for its antimicrobial activity against , , , , , and , respectively. Drechmerin I () showed antimicrobial activities against with an MIC value of 200 μg/mL. The interaction of peptide deformylase with drechmerin I () was investigated by molecular docking.