Adherence of spirochetes to the apical membrane of the colonic epithelium has been well-described in the literature, but the exact pathogenesis leading to symptomatic clinical manifestations is poorly understood. Most cases are found incidentally on the pathological evaluation of colonic biopsies taken during diagnostic or therapeutic colonoscopies. However, whether the colonization of the intestinal mucosa can be attributed to clinical symptoms is a matter of debate. Here, we present a case of intermittent hematochezia attributed to the overwhelming invasion of the colonic mucosa by intestinal spirochetes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136888 | PMC |
| http://dx.doi.org/10.7759/cureus.2970 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gastrointestinal in men who have sex with men: A systematic review.
Int J STD AIDS
December 2024
Sexual health & HIV, University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
Objective: This systematic review aimed to explore any demographic, biological and behavioural characteristics of men who have sex with men (MSM) with diarrhoeagenic .
Design/methods: We searched MEDLINE, EMBASE, and CINAHL for manuscripts published to March 2024. One author screened manuscript abstracts; two authors independently conducted a full text review.
Coexistence of Intestinal Spirochetosis and Colorectal Cancer: Could the Coil be Carcinogenic?
ACG Case Rep J
November 2024
Division of Gastroenterology, Hepatology, and Nutrition, University of Florida College of Medicine, North Florida/South Georgia Veterans Health System, Gainesville, FL.
Intestinal spirochetosis (IS) is an infectious gastrointestinal disease caused by bacteria. We detail an exceedingly rare case of IS with concomitant invasive colorectal adenocarcinoma (CRC) in a 58-year-old man presenting with abdominal discomfort and fever. Colonoscopic evaluation revealed abnormal-appearing, nodular cecal mucosa and a 35 mm rectosigmoid mass.
View Article and Find Full Text PDFBPP43_05035 is a cell surface adhesin that weakens the integrity of the epithelial barrier during infection.
Gut Microbes
September 2024
Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
The anaerobic spirochete causes intestinal spirochetosis, characterized by the intimate attachment of bacterial cells to the colonic mucosa, potentially leading to symptoms such as diarrhea, abdominal pain, and weight loss. Despite the clinical significance of infections, the mechanism of the interaction between and the colon epithelium is not known. We characterized the molecular mechanism of the -epithelium interaction and its impact on the epithelial barrier during infection.
View Article and Find Full Text PDFGut microbiota-derived butyrate improved acute leptospirosis in hamster promoting macrophage ROS mediated by HDAC3 inhibition.
mBio
October 2024
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, China.
Article Synopsis
- Leptospirosis is a re-emerging zoonotic disease that affects both humans and animals, often causing intestinal symptoms and highlighting the importance of gut microbiota in immune response and disease resistance.
- Research indicates that short-chain fatty acids (SCFAs), particularly butyrate, play a protective role against leptospirosis by enhancing immune responses through increased reactive oxygen species (ROS) production.
- The study presents a potential therapeutic pathway through the butyrate-MCT-HDAC3i-ROS signaling axis, suggesting this could be a target for developing strategies to prevent acute leptospirosis.
We present 4 clinical cases of intestinal spirochetosis. The first one presents with chronic diarrhea, and spirochetes are detected in random biopsies. The second is homosexual, HIV+, presents rectal bleeding, colonoscopy shows a straight ulcer and spirochete biopsies show negative treponema PCR.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!