AI Article Synopsis
- Culture, the standard for diagnosing melioidosis (caused by Burkholderia pseudomallei), is evaluated alongside a new lateral flow immunoassay (LFI) to detect capsular polysaccharide in serum samples.
- In a study comparing patients with confirmed melioidosis to those with other infections, the LFI showed a sensitivity of 31.3% and a high specificity of 98.8%.
- Despite its low sensitivity, the LFI offers a quick diagnostic option for melioidosis in areas with limited resources.
Article Abstract
Background: Culture is the gold standard for the diagnosis of melioidosis, an infection caused by Burkholderia pseudomallei. Here we evaluate a lateral flow immunoassay (LFI) to detect B. pseudomallei capsular polysaccharide (CPS) in serum samples.
Methods: Patients with culture from any clinical specimen positive for B. pseudomallei were selected as cases. Patients who were blood culture positive for Staphylococcus aureus, Escherichia coli or Klebsiella pneumoniae as well as those who were malaria or dengue polymerase chain reaction assay positive were selected as controls.
Results: The sensitivity of the LFI was 31.3% (60/192 case patients [95% confidence interval {CI} 24.8 to 38.3]) and the specificity was 98.8% (559/566 control patients [95% CI 97.4 to 99.5]) in serum samples.
Conclusions: Although LFI may have limited sensitivity in serum, it can rapidly diagnose melioidosis in resource-limited settings.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255691 | PMC |
| http://dx.doi.org/10.1093/trstmh/try099 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!