AI Article Synopsis

  • Drug Target Commons (DTC) is an online platform that allows users to manage and standardize bioactivity data related to compound-target interactions.
  • Users can easily search for, upload, edit, annotate, and export curated bioactivity data using various data access methods like API and downloadable formats.
  • The latest version of DTC (version 2.0) includes important updates such as clinical development data, gene-disease associations, and cancer types linked to mutant protein targets, supporting advances in precision oncology and drug repurposing.

Article Abstract

Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of compound-target interaction profiles. End users can search, upload, edit, annotate and export expert-curated bioactivity data for further analysis, using an application programmable interface, database dump or tab-delimited text download options. To guide chemical biology and drug-repurposing applications, DTC version 2.0 includes updated clinical development information for the compounds and target gene-disease associations, as well as cancer-type indications for mutant protein targets, which are critical for precision oncology developments.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146131PMC
http://dx.doi.org/10.1093/database/bay083DOI Listing

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