Background: Infantile choriocarcinoma is usually fatal without appropriate treatment.
Case Characteristics: A 3-month-old boy who presented with respiratory distress, hepatomegaly, amemia and bilateral nodular lesions on chest X-ray.
Observation: Fine-needle liver aspiration revealed necrotic tumour cells. The serum b-hCG level was very high (2057 mIU/L), supporting a diagnosis of infantile choriocarcinoma of the liver. Surgical resection after cisplatin-based multiagent chemotherapy afforded successful remission.
Message: Early treatment of infantile choriocarcinoma can yield a successful outcome.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Choriocarcinoma in neonates and infants: A severe but curable disease.
Pediatr Blood Cancer
August 2024
SIREDO Oncology Centre (Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer), Institut Curie, PSL University, Paris, France.
Article Synopsis
- Choriocarcinoma in neonates and infants (N-CC) is a rare but aggressive cancer often linked with maternal disease, with a median patient age of 6 weeks.
- A study analyzing eight cases revealed that all tumors were diffuse, and most patients underwent a platinum-based treatment regimen, with some requiring surgery for residual tumors.
- Despite a poor overall outcome, including half of the patients dying from the disease, four patients achieved complete remission, highlighting the potential for successful treatment through multimodal therapy.
Cross-individual cancer transmission to children during the gestational and perinatal periods.
Cancer Sci
April 2024
Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan.
Cancer transmission may rarely occur between individuals. Besides through allogenic transplantation, cancer transmission via the hemochorial placenta, which is permissive for cell traffic, has been described in a few reports. Three etiologies of transplacental cancer transmission include (1) maternofetal transmission of maternal cancer cells, (2) transmission of gestational choriocarcinoma to the fetus, and (3) transfer of preleukemic cells from one monozygotic twin to the other.
View Article and Find Full Text PDFGestational trophoblastic neoplasia with concurrent metastasis to the mother and child: a systematic literature review.
J Turk Ger Gynecol Assoc
September 2023
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bibinagar, Hyderabad, India.
Gestational trophoblastic neoplasia (GTN) arising in the placenta and presenting as a metastatic disease concurrently in the mother and the baby is extremely rare. GTN poses a diagnostic dilemma to the treating clinicians. In the current review, an electronic search of Scopus, PubMed, Embase and other databases was conducted for case reports and case series of GTN co-existing or metastatic to both the mother and the baby, published to date.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!