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Acetyl-DL-leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes pathological metabolic brain pattern-case reports.
Nat Commun
September 2024
Department of Neurology, LMU University Hospital, LMU, Munich, Germany.
Isolated REM Sleep Behavior Disorder (iRBD) is considered a prodrome of Parkinson's disease (PD). We investigate whether the potentially disease-modifying compound acetyl-DL-leucine (ADLL; 5 g/d) has an effect on prodromal PD progression in 2 iRBD-patients. Outcome parameters are RBD-severity sum-score (RBD-SS-3), dopamine-transporter single-photon emission computerized tomography (DAT-SPECT) and metabolic "Parkinson-Disease-related-Pattern (PDRP)"-z-score in F-fluorodeoxyglucose positron emission tomography (FDG-PET).
View Article and Find Full Text PDFThe Traumatic Inoculation Process Affects TSPO Radioligand Uptake in Experimental Orthotopic Glioblastoma.
Biomedicines
January 2024
Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Marchioninistr. 15, 81377 Munich, Germany.
Background: The translocator protein (TSPO) has been proven to have great potential as a target for the positron emission tomography (PET) imaging of glioblastoma. However, there is an ongoing debate about the potential various sources of the TSPO PET signal. This work investigates the impact of the inoculation-driven immune response on the PET signal in experimental orthotopic glioblastoma.
View Article and Find Full Text PDFA prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice.
Elife
November 2022
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Parkinson's disease (PD) is a movement disorder characterized by neuroinflammation, α-synuclein pathology, and neurodegeneration. Most cases of PD are non-hereditary, suggesting a strong role for environmental factors, and it has been speculated that disease may originate in peripheral tissues such as the gastrointestinal (GI) tract before affecting the brain. The gut microbiome is altered in PD and may impact motor and GI symptoms as indicated by animal studies, although mechanisms of gut-brain interactions remain incompletely defined.
View Article and Find Full Text PDF[F]FE-PE2I PET is a feasible alternative to [I]FP-CIT SPECT for dopamine transporter imaging in clinically uncertain parkinsonism.
EJNMMI Res
September 2022
Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, Copenhagen, Denmark.
Background: Dopamine transporter (DAT) imaging of striatum is clinically used in Parkinson's disease (PD) and neurodegenerative parkinsonian syndromes (PS) especially in the early disease stages. The aim of the present study was to evaluate the diagnostic performance of the recently developed tracer for DAT imaging [F]FE-PE2I PET/CT to the reference standard [I]FP-CIT SPECT.
Methods: Ninety-eight unselected patients referred for DAT imaging were included prospectively and consecutively and evaluated with [F]FE-PE2I PET/CT and [I]FP-CIT SPECT on two separate days.
[Neural mechanism for modulation of auditory response of the striatum by locomotion].
Nan Fang Yi Ke Da Xue Xue Bao
May 2022
Department of Mathematical Physics, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Objective: To explore whether the characteristic responses to sound stimulations of the auditory neurons in the striatum is regulated in different behavioral states.
Methods: The auditory neurons in the striatum of awake C57BL/6J mice were selected for this study. We recorded the auditory response of the striatum to noises over a long period of time by building a synchronous electrophysiological and locomotion recording system and using glass microelectrode attachment recording.
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