Objective: To review the progress of total ankle arthroplasty (TAA) in treatment of end-stage ankle osteoarthritis (AOA).
Methods: The domestic and foreign literatures about TAA in recent years were reviewed. The current status and progress of TAA were summarized from the results of traditional and computer-assisted TAA clinical outcomes.
Results: End-stage AOA often leads to severe pain and dysfunction, and arthrodesis is still the main selective treatment option. In recent years, with the advancement of surgical techniques and prosthesis design, TAA which can remain joint mobility has increased gradually, and the surgical results also have significant progress. Accurate prosthesis implant and mechanical alignment restoration are critical factors for TAA, and surgery-related malalignment is correlative to the prosthesis failure. Computer assisted patient-specific guide can simplify the TAA procedures and obtain the accuracy of tibia and talus osteotomy.
Conclusion: The clinical efficiency of preoperative CT based patient-specific guide technology for TAA needs further clinical follow-up. Meanwhile, it is necessary to further develop intraoperative navigation and robotic surgery system suitable for TAA.
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http://dx.doi.org/10.7507/1002-1892.201803028 | DOI Listing |
Sci Rep
December 2024
College of Life sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, 271016, China.
The mitochondrial whole genome of Phellinus igniarius was sequenced with the objective of examining the evolutionary relationships amongst related species. The entire mitochondrial genome was assembled using Illumina sequencing technology. The structural annotation and bioinformatics analysis were performed.
View Article and Find Full Text PDFJ Cardiovasc Dev Dis
November 2024
Hochgebirgsklinik Davos, Medicine Campus Davos, 7265 Davos, Switzerland.
Introduction: Balancing the well-documented benefits of regular exercise, particularly its positive impact on cardiovascular risk factors like hypertension, with the potential risks for patients with aortic aneurysms presents a significant challenge. This narrative review aims to summarize the current evidence and guidelines to assist clinicians in making informed exercise and sports recommendations for patients with aortic aneurysms or post-aortic repair.
Methods: Nine clinical trials on the effect of exercise on abdominal aortic aneurysms (AAAs) were identified, including one study on cardiopulmonary exercise testing (CPET) in AAA patients.
Int Immunopharmacol
December 2024
Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
This study aimed to elucidate the protective roles of Immune Response Gene-1 (IRG1) and exogenous itaconate in murine models of hepatic fibrosis and to delineate the underlying mechanistic pathways using both wild-type and IRG1-deficient (IRG1) mice. Primary murine stellate cells (mHSC) and bone marrow-derived macrophages (BMDM) were isolated and cocultured. Hepatocellular fibrosis was induced in vitro using Transforming Growth Factor-beta (TGF-β) to evaluate the protective efficacy of IRG1/itaconate.
View Article and Find Full Text PDFFood Sci Nutr
December 2024
Chemistry Department, College of Education Salahaddin University Erbil Iraq.
Evaluation of of the family Boraginaceae during previous investigations determined numerous therapeutic potentials against inflammatory-related diseases. The present study evaluates the phytochemical, acute toxicity, and hepatoprotective effects of methanolic extracts of (MEAL) against thioacetamide (TAA)-induced liver injury in rats. The phytochemical profiling of MEAL followed a Folin-Ciocalteu and 10% AlCl3 procedure using a spectrophotometer.
View Article and Find Full Text PDFFoot Ankle Surg
December 2024
Department of Orthopedic Surgery, Medical Center Leeuwarden, Leeuwarden, the Netherlands.
Background: Total ankle arthroplasty (TAA) has been developed as treatment for disabling tibiotalar osteoarthritis. TAAs are divided into mobile- and fixed-bearings. The aim was to determine the incidence and trends of fixed- and mobile bearings over time and investigate the association of bearing type and risk of revision after primary TAA in the Netherlands.
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