Cholesterol crystal embolism can be spontaneous or iatrogenic, and it can involve any organ of the gastrointestinal tract, presenting with common gastrointestinal symptoms such as bleeding, perforation, obstruction, and inflammation. It is therefore considered the "great masquerader," requiring a high level of suspicion because the condition is associated with increased morbidity and mortality. We present a 69-year-old man who presented with gastrointestinal bleeding and azotemia. He was found to have cholesterol crystal embolization in the kidney and a duodenal leiomyoma, the latter being an uncommon site to embolize.
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http://dx.doi.org/10.14309/crj.2018.62 | DOI Listing |
Clin Transplant
December 2024
Department of Nephrology, Sundaram Hospital, Trichy, Tamil Nadu, India.
Circ Cardiovasc Imaging
December 2024
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston. (D.F., D.K., K.S., T.N., M.C., I.M., I.-K.J.).
Background: Coronary artery calcium score (CACS) is widely used for risk stratification. However, in patients with established coronary artery disease, its clinical implication and relationship with plaque vulnerability are unclear. We sought to correlate the CACS and plaque vulnerability assessed by optical coherence tomography.
View Article and Find Full Text PDFRedox Biol
December 2024
Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Jiangsu, Nanjing, 210029, China. Electronic address:
After spinal cord injury (SCI), phagocytes endocytose myelin debris to form foam cells, exacerbating the inflammatory response. It has been previously shown that macrophages become foam cells through the phagocytosis of myelin debris via receptor-dependent mechanisms after SCI. Blocking receptor-mediated endocytosis did not completely prevent foam cell formation, so we investigated receptor-independent endocytosis.
View Article and Find Full Text PDFMater Today Bio
December 2024
Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.
The goal of combination cancer therapy, including chemo-phototherapy, is to achieve highly efficient antitumor effects while minimizing the adverse reactions associated with conventional chemotherapy. Nevertheless, enhancing the contribution of non-chemotherapeutic strategies in combination therapy is often challenging because this requires multiple active ingredients to be encapsulated in a single delivery system. However, most commonly used photothermal reagents are challenging to be loaded in large quantities and have poor biocompatibility.
View Article and Find Full Text PDFJ Biomol Struct Dyn
December 2024
Laboratory of Biology and Health, Faculty of Sciences Ben M'Sick, Health and Biotechnology Research Centre, Hassan II University of Casablanca, Casablanca, Morocco.
Squalene synthase (SQS) plays a crucial role in the cholesterol biosynthetic pathway. Its distinctive strategic position makes it a promising candidate for targeting and developing new anti-hypercholesterolemic agents. To uncover novel phytochemical scaffolds as potential inhibitors of SQS, we employed a structure-based virtual screening approach that involves screening 545 phytochemicals collected from Moroccan aromatic and medicinal plants and filtering them based on RMSD values and their affinity towards the target enzyme.
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