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Computational insights into maternal environmental pollutants and folate pathway regulation.
Reprod Toxicol
December 2024
Department of Genomic Research, Sri Sathya Sai Sanjeevani Research Foundation, Palwal, Haryana, India, 121102. Electronic address:
Exposure to environmental pollutants during pregnancy can adversely affect fetal growth and postnatal development. While numerous studies have explored the interaction between environmental toxic chemicals and the folate pathway, few have examined their inhibitory effects on key targets. This computational study identified 27 maternal environmental toxicants using the Comparative Toxicogenomics Database (CTD) and analyzed them to identify their targets.
View Article and Find Full Text PDFNew insights into the relationship of mitochondrial metabolism and atherosclerosis.
Cell Signal
December 2024
Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China; Institue of Cardiovascular Diseases, Jiangsu University, Zhenjiang 212001, China. Electronic address:
Atherosclerotic cardiovascular and cerebrovascular diseases are the number one killer of human health. In view of the important role of mitochondria in the formation and evolution of atherosclerosis, our manuscript aims to comprehensively elaborate the relationship between mitochondria and the formation and evolution of atherosclerosis from the aspects of mitochondrial dynamics, mitochondria-organelle interaction (communication), mitochondria and cell death, mitochondria and vascular smooth muscle cell phenotypic switch, etc., which is combined with genome, transcriptome and proteome, in order to provide new ideas for the pathogenesis of atherosclerosis and the diagnosis and treatment of related diseases.
View Article and Find Full Text PDFBeyond protein folding: The pleiotropic functions of PPIases in cellular processes and microbial virulence.
Biochim Biophys Acta Gen Subj
December 2024
Microbial Pathogenesis and Microbiome Lab, Department of Microbiology, School of Life Sciences, Central University of Rajasthan, Ajmer, Rajasthan, India. Electronic address:
Peptidyl prolyl cis/trans isomerases (PPIases), a ubiquitously distributed superfamily of enzymes, associated with signal transduction, trafficking, assembly, biofilm formation, stress tolerance, cell cycle regulation, gene expression and tissue regeneration, is a key regulator of metabolic disorders and microbial virulence. This review assumes an integrative approach, to provide a holistic overview of the structural and functional diversity of PPIases, examining their conformational dynamics, cellular distribution, and physiological significance. We explore their intricate involvement in cellular processes and virulence modulation in both eukaryotic and prokaryotic systems.
View Article and Find Full Text PDFFamilial Alzheimer's disease mutations in amyloid precursor protein impair calcineurin signaling to NMDA receptors.
J Biol Chem
December 2024
Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center; Memphis, 38163. Electronic address:
Familial Alzheimer's disease (FAD) is frequently associated with mutations in the amyloid precursor protein (APP), which are thought to lead to cognitive deficits by impairing NMDA receptor (NMDAR)-dependent forms of synaptic plasticity. Given the reliance of synaptic plasticity on NMDAR-mediated Ca entry, shaping of NMDAR activity by APP and/or its disease-causing variants could provide a basis for understanding synaptic plasticity impairments associated with FAD. A region of APP (residues 639-644 within APP695) processed by the γ-secretase complex, which generates amyloid β (Aβ) peptides, is a hotspot for FAD mutations.
View Article and Find Full Text PDFInnovative approaches to cationic and anionic (catanionic) amphiphiles self-assemblies: Synthesis, properties, and industrial applications.
Adv Colloid Interface Sci
December 2024
Department of Chemistry and Centre for Advance Study in Chemistry, Panjab University, Chandigarh, India. Electronic address:
Meeting the contemporary demand for the development of functional, biocompatible, and environment friendly self-assembled structures using efficient, cost-effective, and energy-saving methods, the field of colloids has witnessed a surge in interest. Research into cationic and anionic (catanionic) surfactant combinations has gained momentum due to their distinct advantages and synergistic properties in this context. Catanionic self-assemblies have emerged as promising contenders for addressing these requirements.
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