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Advancing Platelet Research Through Live-Cell Imaging: Challenges, Techniques, and Insights.
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School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia.
Platelet cells are essential to maintain haemostasis and play a critical role in thrombosis. They swiftly respond to vascular injury by adhering to damaged vessel surfaces, activating signalling pathways, and aggregating with each other to control bleeding. This dynamic process of platelet activation is intricately coordinated, spanning from membrane receptor maturation to intracellular interactions to whole-cell responses.
View Article and Find Full Text PDFEarly Autonomic Dysfunction in Traumatic Brain Injury: An Article Review on the Impact on Multiple Organ Dysfunction.
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Critical Care and Perioperative Population Health Research (CAPER) Program, Department of Anesthesiology, Duke University, Durham, NC 27708, USA.
Traumatic brain injury (TBI) is a complex condition and a leading cause of injury-related disability and death, with significant impacts on patient outcomes. Extracranial organ involvement plays a critical role in the outcome of patients following TBI. This review aims to provide a comprehensive overview of the pathophysiology, clinical presentation, and challenges in diagnosing patients with autonomic dysfunction after TBI.
View Article and Find Full Text PDFMicrostructure and Mechanical Properties of Mg-8Li-3Al-0.3Si Alloy Deformed Through a Combination of Back-Extrusion and Spinning Process.
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Shanxi Key Laboratory of Magnesium-Based Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
In this work, the Mg-8Li-3Al-0.3Si (LAS830) alloy was prepared by the vacuum melting method. The as-cast alloy was subjected to backward extrusion at 250 °C and then spun at 250 °C.
View Article and Find Full Text PDFThe role of mitochondrial dysfunction in Huntington's disease: Implications for therapeutic targeting.
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School of Medical and Life Sciences, Sunway University, Sunway City, Malaysia; Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (deemed to be University), Sawangi (M), Wardha, India. Electronic address:
Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disorder characterized by cognitive decline, motor dysfunction, and psychiatric disturbances. A common feature of neurodegenerative disorders is mitochondrial dysfunction, which affects the brain's sensitivity to oxidative damage and its high oxygen demand. This dysfunction may plays a significant role in the pathogenesis of Huntington's disease.
View Article and Find Full Text PDFUnveiling the conceptual and intellectual map of care bundle research in ICUs: Trends, key issues, and collaborative networks.
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Kumluca Faculty of Health Sciences, Surgical Nursing Department, Akdeniz University, Antalya, Turkey.
Background: Care bundles are evidence-based practices intended to improve patient outcomes and have become a significant focus in intensive care.
Aim: This study aims to identify research trends, key topics, leading researchers, and significant collaborations in care bundle research within ıntensive care units by mapping the conceptual and intellectual structure of the field.
Study Design: Data were collected from the Web of Science database, covering publications from 2010 to 2024.
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