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Abnormal steroidogenesis and aromatase activity in preeclampsia. | LitMetric

AI Article Synopsis

  • Estrogens and progesterone are crucial for blood vessel development, and abnormalities in these hormones may occur earlier than the typical diagnosis of preeclampsia (PE).
  • In a study involving 90 nulliparous women, those who later developed PE showed distinct hormonal profiles and lower levels of certain hormones compared to women with small gestational age (SGA) and controls.
  • The findings suggest that preeclampsia has specific dysregulations in steroid hormones that could serve as early biomarkers for predicting the condition.

Article Abstract

Introduction: Estrogens and progesterone play critical roles in angiogenesis and vasodilation. Moreover, placental aromatase deficiency is detected in women with preeclampsia (PE) at delivery. We hypothesized that abnormal steroidogenesis occurs much earlier than typical PE diagnosis. Thus, we investigated whether the circulating steroid profile was already disturbed at 24-29 weeks of gestation in women with subsequent PE, and compared the profile with that of women with "placental" small gestational age (SGA) without PE.

Methods: We selected nulliparous women (n = 90) from the MOMA trial, including women with PE (n = 25), SGA (n = 25), and controls (NP; n = 40), for plasma steroid profiling by gas chromatography/mass spectrometry and to measure placental growth factor and soluble fms-like tyrosine kinase-1. Placental aromatase expression was evaluated in a new set of women.

Results: Compared with that of controls, the women with PE had a significantly lower estrone/androstenedione ratio, and exhibited a decreasing trend for estradiol and estrone levels. Lower estriol levels were observed in the SGA group compared to the NP group. Compared with that of controls, the women with PE and SGA had significantly higher levels of 20α-dihydroprogesterone (20α-DHP) and 20α-DHP/progesterone ratios. Pregnenolone sulfate levels were lower in the PE group than in the NP and SGA groups. Decreased expression of aromatase was observed in the PE group compared to the control group.

Discussion: Preeclampsia appears to be characterized by specific steroidogenesis dysregulation long before PE diagnosis, highlighting potential new biomarkers of PE.

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Source
http://dx.doi.org/10.1016/j.placenta.2018.07.004DOI Listing

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