In 2016, the International Consensus Conference 'Sepsis-3' highlighted the value of Sequential Organ Failure Assessment (SOFA) and Quick Sequential Organ Failure Assessment (qSOFA) scores in addition to medical and paramedical clinical reasoning to assess severity and the risk of mortality. The option of using qSOFA scores in healthcare services underlines the important role of nurses in the early detection of sepsis with a risk of unfavourable outcome, raising hopes of reducing the associated mortality.
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http://dx.doi.org/10.1016/j.soin.2018.06.006 | DOI Listing |
Artif Organs
January 2025
Laboratory for Immune Response and Regulatory Medicine, Fujita Health University School of Medicine, Toyoake, Japan.
Background: The pathogenesis of sepsis is thought to be linked to a dysregulated immune response, particularly that involving neutrophils. We have developed a granulocyte adsorption column as a "decoy organ," which relocates the massive inflammation in organs in the body to a blood purification column. This study was conducted to assess the safety and experimental effectiveness of granulocyte monocyte adsorption apheresis-direct hemoperfusion (G1-DHP) in the treatment of patients with sepsis, using a prospective, multicenter design.
View Article and Find Full Text PDFCureus
December 2024
Department of Emergency Medicine, MGM Medical College and Hospital, Navi Mumbai, IND.
Background: During the COVID-19 pandemic, managing respiratory failure in critically ill patients has presented significant challenges. A high-flow nasal cannula (HFNC) has been established as an effective respiratory support modality, offering heated, humidified oxygen at high flow rates. However, concerns persist regarding the potential for aerosol dispersion and the risk of viral transmission, particularly in COVID-19.
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Intensive Care Unit, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
Background: For severe systemic rheumatic diseases (SRDs), therapeutic plasma exchange (TPE) may be applied as a rescue therapy; it usually combined with intravenous immunoglobulin (IVIG) or intravenous methylprednisolone pulse (IVMP) in severe SRDs. However, the necessity of this combination treatment strategy in SRDs remains uncertain.
Objective: This retrospective study aimed to evaluate the effectiveness of TPE alone versus TPE combined with IVIG/IVMP in treating severe SRDs.
J Clin Hypertens (Greenwich)
January 2025
Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
The aim of this study was to explore whether 24-h ambulatory central (aortic) blood pressure (BP) has an advantage over office central aortic BP in screening for hypertension-mediated target organ damage (HMOD). A total of 714 inpatients with primary hypertension and the presence of several cardiovascular risk factors or complications involving clinical HMOD were enrolled. Twenty-four hour central aortic BP was measured by means of a noninvasive automated oscillometric device (Mobil-O-Graph).
View Article and Find Full Text PDFIndian J Pediatr
January 2025
Department of Pediatrics, Bharati Vidyapeeth Medical College and Hospital, Pune, 411043, India.
Objectives: To calculate and assess the role of neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV)/ platelet count (PLT) ratios and their trends as prognostic indicators in neonates and children with sepsis.
Methods: This prospective observational study was planned over a period of two years at a tertiary care teaching hospital. Two hundred seventy children with clinical suspicion of or diagnosed as sepsis were enrolled.
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