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Multilayer entropy-weighted TOPSIS method and its decision-making in ecological operation during the subsidence period of the Three Gorges Reservoir.
Sci Rep
January 2025
State Key Laboratory of Water Resources Engineering and Management, Wuhan University, Wuhan, 430,072, China.
Coordinating the downstream ecological demand and the power generation demand of hydropower stations is an important task in the operation of reservoirs, and how to evaluate the ecological satisfaction of the scheduling process is a difficult problem that needs to be solved urgently. A multi-objective optimal reservoir scheduling model was constructed to coordinate the spawning flow demand of " Four Major Chinese Carps"; The model takes the maximum power generation and the maximum membership degree of downstream river ecological water demand as the objective functions, and uses the dynamic programming multi-objective solution algorithm based on penalty factors to solve the problem, and obtains the non-inferior solution set in each scenario. The multilayer entropy-weighted TOPSIS method was used to study the non-inferior solution of the multi-objective scheduling model of the Three Gorges Reservoir, and the satisfactory solution ranking of the river flow rise process, ecological flow-related requirements, and power generation water requirements was obtained under the four schemes including 4d ~ 7d, which improved the reliability of the evaluation results and made up for the shortcomings of the traditional TOPSIS method in terms of hierarchy and weight science.
View Article and Find Full Text PDFUse of virtual reality to remotely train healthcare professionals in paediatric emergency tracheostomy skills: protocol for a multi-centre, non-inferiority educational interventional study with historical controls.
BMC Surg
January 2025
Division of Immunology, Immunity to Infection, and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Background: The insertion of a tracheostomy is an established technique used to wean patients off ventilatory support, manage secretions in complex conditions, and as a potentially life-saving procedure to bypass upper airway obstruction. Life-threatening complications during aftercare are not uncommon and may be influenced by a lack of education of carers or healthcare providers of children and young people living with a tracheostomy. Education programmes designed and supported by the National Tracheostomy Safety Project are effective, but resources are not available to educate the workforce at scale.
View Article and Find Full Text PDFBeyond Longer Intervals: Advocating for Regular Treatment of Neovascular AMD.
J Clin Med
December 2024
Division of Ophthalmology, Department of Surgery, UMass Chan-Lahey School of Medicine, Burlington, MA 01805, USA.
Personalizing the management of neovascular age-related macular degeneration (nAMD) poses significant challenges for practicing retina specialists and their patients. This commentary addresses some of these complexities, particularly those that arise in the context of an expanding array of intravitreal agents targeting vascular endothelial growth factor (VEGF) and related retinal disease targets. Many of these newer agents approved by the Food and Drug Administration (FDA) for the treatment of nAMD have labeling that indicates that they can provide non-inferior visual outcomes when compared head-to-head with previously available treatments and can be used at significantly extended dosing intervals in some patients.
View Article and Find Full Text PDFMicrofluidic-Chip-Based Formulation and In Vivo Evaluations of Squalene Oil Emulsion Adjuvants for Subunit Vaccines.
Vaccines (Basel)
November 2024
GSK, Rockville Centre for Vaccines Research, Rockville, MD 20850, USA.
Background: Adjuvants play a crucial role in improving the immunogenicity of various antigens in vaccines. Squalene-in-water emulsions are clinically established vaccine adjuvants that improve immune responses, particularly during a pandemic. Current manufacturing processes for these emulsion adjuvants include microfluidizers and homogenizers and these processes have been used to produce emulsion adjuvants to meet global demands during a pandemic.
View Article and Find Full Text PDFEffect of intramuscular treatment with different iron dextran dosages and non-inferiority study to gleptoferron.
Acta Vet Scand
January 2025
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 2, 1870, Frederiksberg C, Denmark.
Background: Prevention of iron deficiency in suckling piglets by intramuscular injection of a standardized amount of iron dextran or gleptoferron in the first days of life can lead to over- or underdosage with respective health risks. Currently, combined iron products containing an active substance against coccidia are also used on farms. When using a combination product targeting two diseases, an adjustment of the necessary amount of iron to prevent anaemia in the frame of a farm-specific treatment protocol is not possible.
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