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Despite a positive result in favour of lung volume reduction surgery (LVRS), from one of the largest randomized controlled trial in thoracic surgery, the identification of poor outcome in certain high-risk groups has resulted in a worldwide decrease in its utilization. Patient selection is the key to successful lung volume reduction which, with the advent of a range of less invasive techniques, has become more complex. The greater variety of potential therapeutic options will inevitably lead to debate amongst treating clinicians. Therefore, to be able to make an informed decision on the best treatment for an individual patient, discussion between clinicians in a multidisciplinary team (MDT) meeting is advisable. The membership of this MDT must include all specialists involved in assessment and subsequent treatment of the patient including non-medical input. There must be robust administrative organization and record of decisions together with inter-disciplinary communication of decisions. Whilst ultimately it is the patient who will benefit from the MDT, individual participants will enhance their continued professional development. The referral pathway into the MDT must be clearly defined and disseminated. Which investigations are to be performed by referrers and which by the specialist centre need to be in an agreed protocol. Specialist input may be required to interpret the results of the latest assessment tools. The decision-making process of the MDT begins with confirmation of basic selection criteria but addresses three main areas of discussion: the definition of target areas of lung for reduction; the presence of collateral, interlobar ventilation and an assessment of individualized risk and benefit. The emphysema or lung volume reduction MDT has been established in several specialist units and its benefits include an increase in referrals overall for LVR. The establishment of an MDT approach to lung volume reduction has now been incorporated into several national guidelines.
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http://dx.doi.org/10.21037/jtd.2018.02.68 | DOI Listing |
Respir Res
December 2024
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Background: The composite physiologic index (CPI) was developed to estimate the extent of interstitial lung disease (ILD) in idiopathic pulmonary fibrosis (IPF) patients based on pulmonary function tests (PFTs). The CALIPER-revised version of the CPI (CALIPER-CPI) was also developed to estimate the volume fraction of ILD measured by CALIPER, an automated quantitative CT postprocessing software. Recently, artificial intelligence-based quantitative CT image analysis software (AIQCT), which can be used to quantify the bronchial volume separately from the ILD volume, was developed and validated in IPF.
View Article and Find Full Text PDFWei Sheng Yan Jiu
November 2024
Shanghai University of Medicine & Health Sciences, Shanghai 200237, China.
Objective: To investigate the protective effect of lycopene on lung oxidative damage induced by atmospheric fine particulate matter(PM_(2.5)) in rats.
Methods: Sixty 7-week-old male Sprague-Dawley rats were randomly divided into six groups: normal control group, PM_(2.
Neuro Oncol
December 2024
Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Background: Hippocampal avoidance during prophylactic cranial irradiation (HA-PCI) is proposed to reduce neurocognitive decline, while preserving the benefits of PCI. We evaluated whether (HA-)PCI induces changes in white matter (WM) microstructure and whether sparing the hippocampus has an impact on preserving brain network topology. Additionally, we evaluated associations between topological metrics with hippocampal volume and neuropsychological outcomes.
View Article and Find Full Text PDFLung India
January 2025
Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Dhanvantari Nagar, Puducherry, India.
Background: The estimated incidence of pulmonary embolism (PE) is around 60-70 cases per 100,000 people annually. The overall mortality rate for massive PE is substantial, ranging from 18% to 65%. We can utilise changes in lung perfusion to stratify patients with PE acutely based on risk, highlighting its diagnostic and prognostic value.
View Article and Find Full Text PDFEur J Cardiothorac Surg
December 2024
Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
Objectives: In patients with interstitial lung disease (ILD), the diaphragm typically rises as the lungs chronically shrink. However, the grade of restriction differs in each patient. It is currently unknown, how disparities between actual and predicted recipient total lung capacity (TLC), impact changes in lung function parameters and long-term outcomes following lung transplantation (LTx).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!