AI Article Synopsis
- - This study assessed how well single- and poly-crystalline ZnO thin films support cell health using two methods: extract and direct contact.
- - Results showed that exposure to poly-crystalline ZnO extracts and direct contact with both types of ZnO thin films decreased cell viability, primarily due to cell adhesion issues caused by zinc.
- - Single-crystalline ZnO thin films demonstrated better short-term compatibility with cells, making them promising candidates for use in biocompatible sensor materials.
Article Abstract
This study evaluated the cytocompatibility of single- and poly-crystalline ZnO thin films using extract and direct contact methods. Exposure to poly-crystalline ZnO extract resulted in reduced cell viability, on average 82%/70% as measured by MTS/LDH assays, respectively. Direct exposure to both single- and poly-crystalline ZnO thin films resulted in reduced cell viability, which was attributed to anoikis due to inhibition of cell adhesion to the substrate by zinc. Intracellular zinc imaging suggests that single crystalline ZnO thin films do not result in a significant change in intracellular zinc concentrations. Overall, the results suggest that single-crystalline ZnO thin films have better short-term (24 h) cytocompatibility and support their potential to serve as a biocompatible sensor material.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124250 | PMC |
| http://dx.doi.org/10.1039/c8tx00061a | DOI Listing |
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