The present study examines the structure of negative affect regulation strategies by confirmatory factor analysis. A total of 264 students ( = 187 women, 65 men) ( = 24 years; = 9.32) took part in this study. Results show a good fit indices for a three facets model: (1) modification of situation (problem-directed action, seeking emotional and instrumental social support, psychological abandonment and social isolation); (2) attentional deployment and cognitive change (distraction, acceptance, gratitude, rumination, reappraisal, spirituality, and social comparison); and (3) response modification (suppression, active and passive physiological, humor and warmth, venting, confrontation, and regulated emotional expression). The scale validity is confirmed through correlations between the expanded of Mood Affect Regulation Scale dimensions including dimensions of dispositional reappraisal and suppression, and hedonic and psychological well-being. Participants report an adaptive profile with high psychological well-being, even if they report low positive affect, suggesting a greater relevance of eudaimonic than hedonic well-being for affect regulation.
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http://dx.doi.org/10.3389/fpsyg.2018.01592 | DOI Listing |
Viruses
December 2024
Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada.
Hepatitis C virus (HCV) disproportionately affects certain sub-populations, including people with experience of incarceration (PWEI). Little is known about how perceptions of HCV and treatment have changed despite simplifications in testing and treatment in carceral settings. Nineteen semi-structured interviews were conducted with people living with or having a history of HCV infection released from Quebec provincial prison.
View Article and Find Full Text PDFViruses
November 2024
Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.
The host enzyme heparanase (HPSE) facilitates the release of herpes simplex virus type 2 (HSV-2) from target cells by cleaving the viral attachment receptor heparan sulfate (HS) from infected cell surfaces. HPSE 2, an isoform of HPSE, binds to but does not possess the enzymatic activity needed to cleave cell surface HS. Our study demonstrates that HSV-2 infection significantly elevates HPSE 2 protein levels, impacting two distinct stages of viral replication.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Department of Psychology, University of Turin, 10124 Turin, Italy.
This study examines the relationship between cognitive and affective flexibility, two critical aspects of adaptability. Cognitive flexibility involves switching between activities as rules change, assessed through task-switching or neuropsychological tests and questionnaires. Affective flexibility, meanwhile, refers to shifting between emotional and non-emotional tasks or states.
View Article and Find Full Text PDFPharmaceutics
December 2024
National Institute of Gastroenterology S. De Bellis, IRCCS Research Hospital, Via Turi 27, 70013 Castellana Grotte, BA, Italy.
Background/objectives: KRT23 was recently discovered as an epithelial-specific intermediate filament protein in the type I keratin family. Many studies have underlined keratin's involvement in several biological processes as well as in the pathogenesis of different diseases. Specifically, KRT23 was reported to affect the structural integrity of epithelial cells and to trigger cellular signaling leading to the onset of cancer.
View Article and Find Full Text PDFPharmaceutics
November 2024
Chengdu Origen Biotechnology Co., Ltd., Chengdu 610036, China.
Interleukin-1 (IL-1) is a pivotal mediator in the pathological progression of osteoarthritis (OA), playing a central role in disease progression. However, the rapid clearance of IL-1 receptor antagonist (IL-1Ra) from the joints may hinder the efficacy of intra-articular IL-1Ra injections in reducing OA-associated pain or cartilage degradation. Sustaining sufficient levels of IL-1Ra within the joints via adeno-associated virus (AAV)-mediated gene therapy presents a promising therapeutic strategy for OA.
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