The article "Expected Budget Impact and Health Outcomes of Expanded Use of Vagus Nerve Stimulation Therapy for Drug-Resistant Epilepsy", written by Molly F. Purser, Deirdre M. Mladsi, Alan Beckman, Francesca Barion, John Forsey was originally published electronically on the publisher's internet portal (currently SpringerLink) on August 24, 2018 without open access.
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http://dx.doi.org/10.1007/s12325-018-0787-9 | DOI Listing |
Environ Sci Technol
January 2025
Environmental Research Group, School of Public Health, Imperial College London, Sir Michael Uren Biomedical Engineering Hub, White City Campus, 80 Wood Lane, London W12 0BZ, United Kingdom.
This study explores the cobenefits of reduced nitrogen dioxide (NO), ozone (O), and particulate matter (PM), through net zero (NZ) climate policy in the UK. Two alternative NZ scenarios, the balanced net zero (BNZP) and widespread innovation (WI) pathways, from the UK Climate Change Committee's Sixth Carbon Budget, were examined using a chemical transport model (CTM). Under the UK existing policy, Business as Usual (BAU), reductions in NO and PM were predicted by 2030 due to new vehicle technologies but plateau by 2040.
View Article and Find Full Text PDFJ Clin Transl Sci
November 2024
Center for Public Health Systems Science, Washington University, St Louis, MO, USA.
Introduction: There is increasing pressure on the federal research budget and shifting public opinions about the value of the academic enterprise. We must develop and apply metrics that demonstrate the broad benefits of research for health and society. The Translational Science Benefits Model (TSBM) measures the impact of large-scale translational science initiatives, such as the National Cancer Institute's Cancer Moonshot.
View Article and Find Full Text PDFWater Res
January 2025
Guangdong Basic Research Center of Excellence for Ecological Security and Green Development, Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds, Institute of Environmental and Ecological Engineering, Guangdong University of Technology, Guangzhou, 510006, China.
Riverine NO and N fluxes, key components of the global nitrogen budget, are known to be influenced by river size (often represented by average river width), yet the specific mechanisms behind these effects remain unclear. This study examined how environmental and microbial factors influenced sediment NO and N fluxes across rivers with varying widths (2.8 to 2,000 m) in China.
View Article and Find Full Text PDFBackground: Although the success rate of novel treatments for CNS diseases is low, this has not limited the enthusiasm of academic and industry neuroscientists to undertake novel drug discovery approaches for the treatment of Alzheimer's Disease-Related Dementias (ADRD) due to the significant unmet need. A first major obstacle in the development of promising treatments for ADRD and other CNS disorders is the need for well-validated targets linked to the disease process. Partial and incomplete knowledge about the biology of the selected molecular target(s) often limit their chance to translate into successful drug discovery projects.
View Article and Find Full Text PDFClin J Pain
January 2025
Department of Anesthesiology Critical Care Medicine, The Saban Research Institute at Children's Hospital Los Angeles, The Biobehavioral Pain Lab.
Objectives: Chronic pain is a leading cause of morbidity in children and adolescents globally but can be managed with a combination of traditional Western medicine and integrative medicine (IM) practices. This combination has improved various critical health outcomes, such as quality-of-life, sleep, pain, anxiety, and healthcare utilization. These IM practices include acupuncture, yoga, biofeedback, massage, mindfulness, or any combination of these modalities.
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