AI Article Synopsis
- Initial studies suggested that sensory information from the thalamus is processed in a serial manner through primary sensory cortex layers, particularly from layer 4 to layers 2/3 and 5.
- Recent research indicates that layer 5 neurons can directly process thalamic input, raising questions about the role of layer 2/3 neurons in this sensory processing.
- New experiments show that layer 2/3 pyramidal neurons significantly amplify sensory responses in layer 5 neurons, with the amplification dependent on the speed of the sensory stimulus, suggesting they help regulate sensory input strength in deeper layers.
Article Abstract
Initial anatomical and physiological studies suggested that sensory information relayed from the periphery by the thalamus is serially processed in primary sensory cortical areas. It is thought to propagate from layer 4 (L4) up to L2/3 and down to L5, which constitutes the main output of the cortex. However, more recent experiments point toward the existence of a direct processing of thalamic input by L5 neurons. Therefore, the role of L2/3 neurons in the sensory processing operated by L5 neurons is now highly debated. Using cell type-specific and reversible optogenetic manipulations in the somatosensory cortex of both anesthetized and awake mice, we demonstrate that L2/3 pyramidal neurons play a major role in amplifying sensory-evoked responses in L5 neurons. The amplification effect scales with the velocity of the sensory stimulus, indicating that L2/3 pyramidal neurons implement gain control in deep-layer neurons.
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| http://dx.doi.org/10.1016/j.celrep.2018.08.038 | DOI Listing |
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