Familial Dyskeratotic Comedones.

Skinmed

From the Departments of Dermatology, Venereology and Leprology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

Published: October 2019

AI Article Synopsis

  • A 21-year-old man has been dealing with asymptomatic comedones and inflammatory papulonodules for 7 years, affecting multiple body areas.
  • Physical exam shows black papules with keratotic plugs and a few painful nodules, along with pocklike scars primarily on the face and back.
  • A skin biopsy indicates keratin-filled invaginations and signs of dyskeratosis, and the patient has a family history of similar skin issues.

Article Abstract

A 21-year-old man presented with extensive asymptomatic comedones and inflammatory papulonodules that had been present for the previous 7 years. The lesions had first appeared on the upper part of the trunk, subsequently spreading to the face, arms, axillae, thighs, groin, and buttocks. Physical examination revealed numerous monomorphic discrete black papules with firm central keratotic plugs. A few painful, inflamed nodules were present over the back (Figure 1). Pocklike scars were located predominantly over the face and back. His general health was otherwise normal, and he had not received any prior treatment for this condition. His father had similar lesions. Skin biopsy from the hyperkeratotic lesions revealed a crater-like invagination filled with lamellar keratinous material with foci of dyskeratosis (Figure 2).

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