The nickel/( S)-Binapine complex was found to be an efficient catalyst for asymmetric hydrogenation of β-acetylamino vinylsulfones to afford chiral β-Amido sulfones with excellent yields and enantioselectivities (up to 95% yields and >99% ee). This protocol has good compatibility with a series of substituted ( Z)-β-acetylamino vinylsulfones or Z/ E isomeric mixtures. A gram-scale reaction has also been achieved in the presence of a 0.2 mol % catalyst loading.
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| http://dx.doi.org/10.1021/acs.orglett.8b02579 | DOI Listing |
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