AI Article Synopsis
- Chronic renal disease and acute renal injury can lead to serious conditions like end-stage renal disease or renal failure.
- Sonoporation, a technique utilizing ultrasound-targeted microbubble destruction (UTMD), enhances the delivery of genes into kidney tissues, aiming to improve treatment outcomes.
- The article explores how UTMD can repair damaged tissues and aid in stem cell therapy for various kidney diseases, including diabetic nephropathy and renal carcinoma, positioning it as a promising alternative to traditional gene therapy methods.
Article Abstract
Chronic renal disease or acute renal injury could result in end-stage renal disease or renal failure. Sonoporation, induced by ultrasound-targeted microbubble destruction (UTMD), has evolved as a new technology for gene delivery. It increases the transfection efficiency of the genes into target kidney tissues. Moreover, UTMD-mediated gene delivery can directly repair the damaged tissues or improve the recruitment and homing of stem cells in the recovery of injured tissues, which has the potential to act as a non-viral and effective method to current gene therapy. This article reviews the mechanisms and applications of UTMD in terms of renal disease, including diabetic nephropathy, renal carcinoma, acute kidney injury, renal interstitial fibrosis, nephrotoxic nephritis, urinary stones, and acute rejection.
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| http://dx.doi.org/10.1089/hum.2018.070 | DOI Listing |
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