The importance of fucoidan as a functional ingredient in food, health products, and pharmaceutics is well-recognized due to its beneficial biological effects. Fucoidan is usually extracted from brown seaweeds, including . Fucoidan exhibits beneficial bio-activity and has antioxidant, anticancer, and anticoagulant properties. This review focuses on the biological activity of -derived fucoidan and investigates its structure⁻activity or fraction⁻activity relationship. It also describes several fucoidan extracts, along with their claimed anticancer effects. It aims to provide information and thoughts for future research such as the development of fucoidan into functional foods or nutraceuticals.
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http://dx.doi.org/10.3390/md16090321 | DOI Listing |
Int J Biol Macromol
December 2024
School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China. Electronic address:
Fucoidan has various physiological activities, and its structure is also different according to different brown algae. In this study SNF (Sargassum Naozhouense fucoidan) was extracted by acid extraction method, and its relative molecular weight was determined to be 631.40 kDa.
View Article and Find Full Text PDFMar Drugs
November 2024
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Peritoneal dialysis (PD) serves as a home-based kidney replacement therapy with increasing utilization across the globe. However, long-term use of high-glucose-based PD solution incites repeated peritoneal injury and inevitable peritoneal fibrosis, thus compromising treatment efficacy and resulting in ultrafiltration failure eventually. In the present study, we utilized human mesothelial MeT-5A cells for the in vitro experiments and a PD mouse model for in vivo validation to study the pathophysiological mechanisms underneath PD-associated peritoneal fibrosis.
View Article and Find Full Text PDFFood Sci Nutr
December 2024
The Third Affiliated Hospital of Guangxi Medical University, The Second People's Hospital of Nanning City Nanning China.
Cystitis glandularis (CG), known as a pre-gradual lesion in the bladder, is the pathological changes in the vesical mucosa characterized by inflammatory invasion and chronic obstruction. Clinically, effective treatment against CG is prescribed only when using drug therapy. Fucoidan, the naturally extractive polysaccharide, is well-reported bioactive compound with anti-inflammatory and immunoregulatory properties.
View Article and Find Full Text PDFCells
November 2024
School of Biosystems and Food Engineering, University College Dublin, D04 V1W8 Dublin, Ireland.
This study aimed to investigate the biological activity of crude and purified laminarin and fucoidan samples extracted from Irish brown macroalgae species and . The antioxidant capacity of the samples was evaluated using the 2,2-diphenyl-1-picrylhydrazyl and ferric-reducing antioxidant power assays. The anti-inflammatory potential of the samples was analysed using the cyclooxygenases inhibition activity, and the antidiabetic activity was evaluated using a dipeptidyl peptidase-4 inhibitor screening assay.
View Article and Find Full Text PDFMar Drugs
November 2024
Teagasc Ashtown Food Research Centre, Teagasc, 15 Dublin, Ireland.
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