This study quantifies the operational and safety impacts of setting posted speed limits below engineering recommendations using field data from rural roads in Montana. Vehicle operating speeds and historical crash data were collected at multiple sites with posted speed limits set equal to engineering recommendations and sites with posted speed limits set lower than engineering recommendations. Linear, quantile and logistic regression models were estimated to predict mean operating speed, 85th percentile operating speed and speed limit compliance, respectively, as a function of various roadway characteristics and level of speed enforcement. The Empirical-Bayes before-after approach was also used to develop crash modification factors (CMFs) that describe the expected change in total and fatal + injury crash frequency when setting posted speed limits lower than engineering recommendations. Because safety data were collected over a long time period, temporal adjustments were incorporated to account for yearly changes in crash reporting, traffic characteristics and other variables. The results revealed that speed limit compliance worsened as the difference between the engineering recommended and posted speed limits increased. The presence of verified heavy police enforcement reduced both mean and 85th-percentile operating speeds by approximately 4 mph and increased speed limit compliance. The safety analysis found a statistically significant reduction in total, fatal + injury, and property damage only (PDO) crash frequency at locations with posted speed limits set 5 mph lower than engineering recommendations. Locations with posted speed limits set 10 mph lower than engineering recommendations experienced a decrease in total and PDO crash frequency, but an increase in fatal + injury crash frequency. The safety effects of setting speed limits 15 to 25 mph lower than engineering recommendations were less clear, as the results were not statistically significant, likely due to the small sample of sites included in the evaluation. Overall, the results suggest that setting posted speed limits 5 mph lower than the engineering recommended practice may result in operating speeds that are more consistent with the posted speed limits and overall safety benefits.
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http://dx.doi.org/10.1016/j.aap.2018.08.029 | DOI Listing |
J Extracell Biol
January 2025
Cell Biology Unit & Platform for Imaging Cells and Tissues, de Duve Institute UCLouvain Brussels Belgium.
The extracellular vesicle release in red blood cell concentrates reflects progressive accumulation of storage lesions and could represent a new measure to be implemented routinely in blood centres in addition to haemolysis. Nevertheless, there is currently no standardized isolation protocol. In a previous publication, we developed a reproducible ultracentrifugation-based protocol (20,000 × protocol) that allows to classify red blood cell concentrates into three cohorts according to their vesiculation level.
View Article and Find Full Text PDFJ Pathol Inform
January 2025
University of Michigan Medical School, Department of Pathology, 2800 Plymouth Road, Ann Arbor, MI 48109-2800, USA.
Digital pathology is a tool of rapidly evolving importance within the discipline of pathology. Whole slide imaging promises numerous advantages; however, adoption is limited by challenges in ease of use and speed of high-quality image rendering relative to the simplicity and visual quality of glass slides. Herein, we introduce Iris, a new high-performance digital pathology rendering system.
View Article and Find Full Text PDFNatl J Maxillofac Surg
November 2024
Department of Forensic Medicine and Toxicology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Introduction: In Uttar Pradesh, India, there are many fatal head injuries as a result of road traffic accidents (RTAs). Studying the pattern and distribution of intracranial hemorrhages, a frequent complication of severe head trauma might provide vital information on the efficacy of traffic safety regulations. To improve road safety tactics and lower fatal head injuries in Uttar Pradesh, this study intends to assess the effect of road safety measures on the frequency and distribution of intracranial hemorrhages in fatal head injury patients.
View Article and Find Full Text PDFFront Physiol
January 2025
Internet Society for Sport Science, Auckland, New Zealand.
Introduction: Meta-analysts have found that high-intensity interval training (HIIT) improves physical performance, but limited evidence exists regarding its effects on highly trained athletes, measures beyond maximum oxygen uptake ( O), and the moderating effects of different types of HIIT. In this study, we present meta-analyses of the effects of HIIT focusing on these deficits.
Methods: The effects of 6 types of HIIT and other moderators were derived from 34 studies involving highly trained endurance and elite athletes in percent units via log-transformation from separate meta-regression mixed models for sprint, time-trial, aerobic/anaerobic threshold, peak speed/power, repeated-sprint ability, O, and exercise economy.
Embryogenesis is remarkably robust to temperature variability, yet there is limited understanding of the homeostatic mechanisms that offset thermal effects during early development. Here, we measured the thermal acclimation response of upper thermal limits and profiled chromatin state and the transcriptome of embryos (Bownes Stage 11) using single-nuclei multiome ATAC and RNA sequencing. We report that thermal acclimation, while preserving a common set of primordial cell types, rapidly shifted the upper thermal limit.
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