TERT catalyzes telomere maintenance. While silenced in most normal somatic cells, TERT is expressed in cancer, often due to promoter mutations, facilitating replicative immortality. In this issue of Cancer Cell, Mancini et al. demonstrate that GABPβ1L is required for mutant TERT promoter activity, thus identifying a potential therapeutic target.
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| http://dx.doi.org/10.1016/j.ccell.2018.08.011 | DOI Listing |
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Effects of a Distributed Form of Constraint-Induced Movement Therapy for Clinical Application: The Keys Treatment Protocol.
Brain Sci
January 2025
Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Background/aim: Currently, there are limited evidence-based protocols for improving upper extremity (UE) motor function after stroke. The Keys protocol, a distributed form of constraint-induced movement therapy (CIMT), delivers CIMT components in fewer hours per day over an extended period, fitting outpatient rehabilitation schedules and third-party payor models. This pilot study aimed to assess the effectiveness of the Keys protocol in enhancing UE capacity and performance poststroke.
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Proc Natl Acad Sci U S A
January 2025
National Institute of Biological Sciences, Beijing 102206, China.
Sleep need accumulates during waking and dissipates during sleep to maintain sleep homeostasis (process S). Besides the regulation of daily (baseline) sleep amount, homeostatic sleep regulation commonly refers to the universal phenomenon that sleep deprivation (SD) causes an increase of sleep need, hence, the amount and intensity of subsequent recovery sleep. The central regulators and signaling pathways that govern the baseline and homeostatic sleep regulations in mammals remain unclear.
View Article and Find Full Text PDFImpact of Varying Sleep Pressure on Daytime Sleep Propensity in Healthy Young and Older Adults.
Clocks Sleep
January 2025
Circadian Physics Group, School of Physics, University of Sydney, Sydney, NSW 2006, Australia.
Fixed sleep schedules with an 8 h time in bed (TIB) are used to ensure participants are well-rested before laboratory studies. However, such schedules may lead to cumulative excess wakefulness in young individuals. Effects on older individuals are unknown.
View Article and Find Full Text PDFBimodal Patterns of Locomotor Activity and Sleep in : A Model for Their Simulation.
Nat Sci Sleep
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Department of Insect Genetics, Institute of Cytology and Genetics of the Siberian Branch, the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
Purpose: Two previously proposed modelling approaches to explain the bimodal pattern of activity and/or sleep in are based on 1) the concept of morning and evening oscillators underlying the peaks of activity in the morning and evening, respectively, and 2) the concept of two cycles of buildup and decay of sleep pressure, gated only by the circadian oscillator. Previously, we simulated 24-h alertness-sleepiness curves in humans using a model postulating the circadian modulation of the buildup and decay phases of two (wake and sleep) homeostatic processes. Here, we tested whether a similar model could be applied to simulate the bimodal 24-h rhythm of fly locomotor activity and sleep.
View Article and Find Full Text PDFContact Lenses in Therapeutic Care: A Comprehensive Review of Past Innovations, Present Applications, and Future Directions.
Adv Exp Med Biol
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Department of Optometry, University of Benin, Benin City, Nigeria.
Contact lenses have become integral tools in the realm of ocular therapeutics, extending beyond their primary function of refractive correction to encompass a diverse array of therapeutic applications. This review explores the evolving role of contact lenses in managing various ocular conditions, highlighting their efficacy in enhancing patient outcomes. Initially developed to correct refractive errors, contact lenses now serve as effective vehicles for delivering medications directly to the ocular surface, offering targeted treatment for conditions such as dry eye syndrome and corneal ulcers.
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