A highly modular, diastereoselective one-pot-synthesis of 1,3-diamines with three contiguous stereogenic centers is reported. Our method provides a fast and efficient access to 1,2- anti-2,3- anti-1,3-diamines from three readily available building blocks. This Bi(OTf)-catalyzed reaction is insensitive to air and moisture and can be performed on a multigram scale.
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| http://dx.doi.org/10.1021/acs.joc.8b01925 | DOI Listing |
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