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Lysosome-related proteins may have changes in the urinary exosomes of patients with acute gout attack.
Eur J Med Res
January 2025
Clinical Laboratory Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Background: The autophagy-lysosome is intricately linked to the development of gout. At present, the diagnosis and monitoring of gout are mainly invasive tests, which cannot predict the occurrence of gout in the acute phase, and bring new pain to patients. This study focuses on the changes of lysosome-related proteins in urinary exosomes of patients with acute gout attack to explore the potential noninvasive biomarkers clinical application value.
View Article and Find Full Text PDFPulse Irrigation Reduces Rate of Postoperative Hematoma Following Breast Reduction.
Aesthetic Plast Surg
January 2025
Division of Plastic and Reconstructive Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai, 10 Union Square East, Suite 2L, New York, 10003, USA.
Purpose: Breast reduction (BR) involves a large surface area of manipulated tissue, increasing the risk of postoperative hematoma. Pulse irrigation (PI) uses a device to deliver intermittent pressurized irrigant intraoperatively. This study aims to evaluate whether the use of PI is associated with reduced incidence of postoperative hematoma after BR.
View Article and Find Full Text PDFProlonged nightly fasting in older adults with memory decline: A single-group pilot study exploring changes in cognitive function and cardiometabolic risk factors.
J Clin Transl Sci
December 2024
College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Introduction: Older age significantly increases risk for cognitive decline. A growing number of older adults (≥ 65 years) experience cognitive decline that compromises immediate and/or long-term health. Interventions to mitigate cognitive decline are greatly needed.
View Article and Find Full Text PDFImproving the Stability of Gas Diffusion Electrodes for CO Electroreduction to Formate with Sn and In-Based Catalysts at 500 mA cm: Effect of Electrode Design and Operation Mode.
ACS Omega
January 2025
Department of Chemical and Biological Engineering, The University of British Columbia, 2360 East Mall, Vancouver V6T 1Z3, Canada.
The electrochemical carbon dioxide reduction reaction (CORR) using renewable electricity sources could provide a sustainable solution for generating valuable chemicals, such as formate salt or formic acid. However, an efficient, stable, and scalable electrode generating formate at industrially viable current densities (>100 mA cm) is yet to be developed. Sn or In-based catalysts in gas diffusion electrodes (GDE) can efficiently produce formate.
View Article and Find Full Text PDFA multicenter Phase II randomized, placebo-controlled single-blind trial with the SV2A ligand seletracetam in photosensitive epilepsy patients.
Epilepsy Behav
January 2025
Translational Neuropharmacology Lab, NIFE, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hannover, Germany. Electronic address:
The objective of this study was to evaluate the effect of seletracetam (SEL), a potent modulator of synaptic vesicle glycoprotein 2A (SV2A), in patients with photoparoxysmal EEG response (PPR) to intermittent photic stimulation (IPS) as proof-of-principle of efficacy in patients with epilepsy. In this multicenter, single-blind Phase II study, adults with photosensitive epilepsy, with/without concomitant antiseizure medication therapy, underwent IPS under 3 eye conditions (at eye closure, eyes closed and eyes open) after a single oral dose of placebo (day - 1) or SEL (day 1; 0.5, 1, 2, 4, 10, or 20 mg).
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