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Recurrent respiratory papillomatosis (RRP) is a challenging disease to manage, due to its highly recurring nature and the lack of a definitive treatment. It is characterized by the presence of benign papillomatous lesions caused by the human papillomavirus (HPV), which can pose a threat to the patient's airway patency and restrict their breathing ability. We present the case of a 64-year-old patient with a history of papillomas in the trachea and bronchi, treated with endobronchial cryotherapy.

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Update on Pathologic Conditions, Imaging Findings, Prevention, and Management of Human Papillomavirus-related Neoplasms.

Radiographics

August 2024

From the Departments of Radiology (V.S.K., S.G., B.D., R.G., I.E.) and Pathology (P.V.), University of Texas Health San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229; Department of Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (M.C., S.R.P.); Department of Radiology, Le Bonheur Children's Hospital, Memphis, Tenn (P.K.S.); and Department of Radiology, University of Pittsburg Medical Center, Pittsburg, Pa (A.K.D.).

Article Synopsis
  • Human papillomavirus (HPV) is the leading sexually transmitted infection linked to various cancers, including oropharyngeal, cervical, and anogenital malignancies, with both low-risk and high-risk subtypes causing different health issues.
  • Recent studies highlight significant differences in treatment response and prognosis for HPV-associated cancers, leading to their classification in the World Health Organization framework.
  • Advances in imaging techniques are crucial for early detection, diagnosis, and monitoring of HPV-related cancers, while updated screening and vaccination guidelines aim to reduce the disease burden and explore novel treatment options like immunotherapy.
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Bronchial Basaloid Papillary Tumor of Uncertain Malignant Potential: A Case Report.

Int J Surg Pathol

February 2025

Department of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province, China.

Bronchial papillomas are benign tumors, which can be divided into different subtypes based on the cellular features. So far, no bronchial papilloma with basaloid cell features has been reported. We report a bronchial basaloid papillary tumor in a 67-year-old woman.

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Tracheal papillomatosis is a rare and challenging condition characterized by the development of benign tumors in the trachea and bronchial tree. This case report presents a 53-year-old female with refractory papillomatosis and mediastinal lymphadenopathy. Despite three previous resections, the papilloma recurred, causing moderate tracheal narrowing and symptoms mimicking severe persistent asthma.

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Recurrent respiratory papillomatosis (RRP), which is usually benign, is an intractable disease characterized by recurrent papillomas (wart-like lesions). Although it most commonly involves the mucosal epithelial lining of the upper respiratory tract, on rare occasions, it can also involve lung parenchyma. RRP carries the risk of malignant transformation, most often to non-small-cell squamous lung cancer.

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