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Quantitative, high-sensitivity measurement of liquid analytes using a smartphone compass.
Nat Commun
March 2024
Applied Physics Division, National Institute of Standards and Technology, Boulder, CO, 80305, USA.
Smartphone ubiquity has led to rapid developments in portable diagnostics. While successful, such platforms are predominantly optics-based, using the smartphone camera as the sensing interface. By contrast, magnetics-based modalities exploiting the smartphone compass (magnetometer) remain unexplored, despite inherent advantages in optically opaque, scattering or auto-fluorescing samples.
View Article and Find Full Text PDFImprinted Hydrogel Nanoparticles for Protein Biosensing: A Review.
ACS Sens
August 2023
CIQUP/IMS, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre 687, s/n, Porto 4169-007, Portugal.
Over the past decade, molecular imprinting (MI) technology has made tremendous progress, and the advancements in nanotechnology have been the major driving force behind the improvement of MI technology. The preparation of nanoscale imprinted materials, i.e.
View Article and Find Full Text PDFHydrogel gratings with patterned analyte responsive dyes for spectroscopic sensing.
RSC Adv
December 2021
Process Instruments (UK) Ltd Turf Street Burnley BB11 3BP UK
This is an unprecedented report of hydrogel gratings with an analyte responsive dye immobilised in alternating strips where the patterned dye is its own dispersive element to perform spectroscopy. At each wavelength, the diffraction efficiency of hydrogel gratings is a function of dye absorbance, which in turn is dependent on the concentration of analytes in samples. Thus, changes in intensity of diffracted light of hydrogel gratings were measured for sensing of analytes.
View Article and Find Full Text PDFStimuli-sensitive cross-linked hydrogels as drug delivery systems: Impact of the drug on the responsiveness.
Int J Pharm
April 2020
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Responsiveness of drug delivery systems (DDS) against internal and external stimuli attracts wide interest as a mechanism that can provide both site-specific release at the target place and feedback regulated release rate. Biological environment is quite complex and the effects that the intricate medium may have on the effectiveness of the stimulus have received certain attention. Differently, the impact that the drug loaded may have itself on the responsiveness of the DDS has been underestimated.
View Article and Find Full Text PDFSimple Self-Referenced Luminescent pH Sensors Based on Upconversion Nanocrystals and pH-Sensitive Fluorescent BODIPY Dyes.
Anal Chem
June 2019
Division Biophotonics , BAM Federal Institute for Materials Research and Testing, Richard-Willstaetter-Str. 11 , 12489 Berlin , Germany.
We present the design and fabrication of pH responsive ratiometric dual component sensor systems based on multicolor emissive upconversion nanoparticles (UCNP) and pH sensitive BODIPY dyes with tunable p K values embedded into a polymeric hydrogel matrix. The use of NIR excitable NaYF:Yb,Tm UCNPs enables background free read-out. Furthermore, the spectrally matching optical properties of the UCNPs and the dyes allow the UCNPs to serve as excitation light source for the analyte-responsive BODIPY as well as intrinsic reference.
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