In order to study the features of hemodynamics in the vertebral artery (VA), depending on the biomechanical disorders of the cervical spine (CS) and the musculoskeletal system as a whole 105 patients (53 females and 52 males, mean age - 38±5,9 years) having signs of the Vertebrobasilar insufficiency on the background of biomechanical disorders of the CS and the locomotor system as a whole were examined. The control group included 50 practically healthy persons (25 females and 25 males, mean age - 37±5,6 years). Physical examination included a clinical-neurological, vertebro-neurological examination (visual assessment of violations of statics and dynamics of the musculoskeletal system, measuring the craniovertebral angle (CVA) using a photogrammetric method, manual diagnostics for the detection of muscular-tonic syndromes and musculoskeletal dysfunction) and Doppler ultrasound of extra- and intracranial segments of VA. It was revealed the relationship between the violation of hemodynamics in vertebrobasilar system and pathobiomechanical changes of the musculoskeletal system in patients of young age. The leading pathogenetic role in the onset of hemodynamic disorders in VA belongs to a non-optimal static stereotype in the cervical region in the form of displacement of the regional center of gravity forward with the formation of a forward head position. It was revealed a positive correlation between the value of CVA and the degree of mobility of the craniovertebral transition by A. Stoddart (r = +0.79, p <0.05) and also - a negative correlation between CVA value and the level of blood flow reduction in VA during functional rotational tests (r=-0,69, p<0,05).
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Ann Med
December 2025
Department of Joint and Sports Medicine, Zhongnan Hospital, Wuhan University, Wuhan, China.
As life expectancy among patients infected with the human immunodeficiency virus (HIV) increases, a growing number of complications have been observed. This population displays an elevated risk of ischemic necrosis of the femoral head in comparison to the general population, which may be attributed to HIV infection, antiretroviral medication use, and hormone application. Patients infected with the human immunodeficiency virus (HIV) who also have necrosis of the femoral head tend to present at an earlier age, with a rapid disease progression and a high incidence of bilateral onset.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, University of California, Los Angeles, California, United States.
Purpose: The optic nerve (ON) is mechanically perturbed by eye movements that shift cerebrospinal fluid (CSF) within its surrounding dural sheath. This study compared changes in ON length and CSF volume within the intraorbital ON sheath caused by eye movements in healthy subjects and patients with optic neuropathies.
Methods: Twenty-one healthy controls were compared with 11 patients having primary open angle glaucoma (POAG) at normal intraocular pressure (IOP), and 11 with chronic non-arteritic anterior ischemic optic neuropathy (NA-AION).
Metab Brain Dis
January 2025
Hepato-Neuro Laboratory, Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, 900, Rue Saint-Denis - Pavillon R, R08.422, Montréal (Québec), H2X 0A9, Canada.
Sarcopenia and hepatic encephalopathy (HE) are complications of chronic liver disease (CLD), which negatively impact clinical outcomes. Hyperammonemia is considered to be the central component in the pathogenesis of HE, however ammonia's toxic effects have also been shown to impinge on extracerebral organs including the muscle. Our aim was to investigate the effect of attenuating hyperammonemia with ornithine phenylacetate (OP) on muscle mass loss and associated molecular mechanisms in rats with CLD.
View Article and Find Full Text PDFCalcif Tissue Int
January 2025
Department of Bioengineering, Temple University, 1947 N. 12th St, Philadelphia, PA, 19122, USA.
Bone mechanical function is determined by multiple factors, some of which are still being elucidated. Here, we present a multivariate analysis of the role of bone tissue composition in the proximal femur stiffness of cadaver bones (n = 12, age 44-93). Stiffness was assessed by testing under loading conditions simulating a sideways fall onto the hip.
View Article and Find Full Text PDFNaturwissenschaften
January 2025
Sea Turtle Research and Application Center, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye.
Information on the age of vertebrate species such as sea turtles is crucial for planning management and conservation actions. The age of sea turtles has been estimated by skeletochronological analysis using skeletal growth marks in different bones. This study focused on the consistency of the number of visible lines of arrested growth (LAG) observed from the humerus and phalanx bone used for age estimation in Chelonia mydas and Caretta caretta.
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