AI Article Synopsis
- The study examines the relationship between SCUBE1 levels and polycystic ovary syndrome (PCOS) in lean women, suggesting PCOS may signify an early stage of metabolic syndrome linked to cardiovascular issues.
- Researchers analyzed 90 women with PCOS and 100 healthy controls, confirming that those with PCOS had significantly higher SCUBE1 levels (5.9 ng/mL) compared to controls (4.2 ng/mL).
- Despite increased SCUBE1 levels in women with PCOS, the study found no correlation between SCUBE1 and hormonal or metabolic factors, implying its potential role as an early biomarker for future cardiovascular problems.
Article Abstract
Objective: Polycystic ovary syndrome (PCOS) is thought to represent an early manifestation of metabolic syndrome, which is associated with cardiovascular disease. Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-epidermal growth factor domain-containing protein 1 (SCUBE1) is a platelet activation marker that plays important roles in vascular biology and has been closely linked to cardiovascular events. In the present study, we investigated SCUBE1 levels in lean glucose-tolerant women with PCOS and assessed the possible association between SCUBE1 levels and hormonal and metabolic features of women with PCOS.
Materials And Methods: The study population consisted of 90 lean [body mass index (BMI) <25 kg/m] women who were diagnosed as having PCOS using the Rotterdam criteria and 100 age- and BMI-matched healthy controls with no clinical or biochemical feature of hyperandrogenism. Glucose tolerance was evaluated in all subjects before recruitment using the 2 h 75 g oral glucose tolerance test, and only those exhibiting normal glucose tolerance were enrolled. Hormonal and metabolic parameters, and serum SCUBE1 levels were evaluated.
Results: Circulating SCUBE1 levels were significantly higher in women with PCOS than in controls (5.9±3.9 vs. 4.2±1.4 ng/mL, p=0.022). No association between SCUBE1 level and clinical or biochemical parameters was found in the control or PCOS group.
Conclusion: SCUBE1 levels are elevated in women with PCOS compared with those in healthy controls; thus, this protein may be an early biomarker of cardiovascular disease later in life.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127468 | PMC |
| http://dx.doi.org/10.4274/tjod.25826 | DOI Listing |
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