Purpose: Resorption of the alveolar bone is an unavoidable consequence of tooth extraction when appropriate alveolar ridge preservation (ARP) measures are not taken. The objective of this trial was to test the hypothesis that dimensional changes in the alveolar bone after tooth extraction would be reduced by inserting an equine collagen membrane and a collagen cone to fill and seal the alveolus (as ARP), in comparison to extraction with untreated alveoli.
Methods: In this randomized clinical trial, 31 patients were directly treated with the collagen material after extraction of a tooth from the maxilla (the ARP group). Twenty-nine patients served as the control group. After extraction, no further treatment (i.e., no socket preservation measures) was performed in the control group. Changes in the alveolar process immediately after extraction and after an 8 (±1)-week healing period were evaluated 3-dimensionally. Blinded analyses were performed after superimposing the data from the digitalized impressions and surfaces generated by cone-beam computed tomography.
Results: Both the ARP and control groups showed a reduction of bone in the alveolar area after tooth extraction. However, significantly less bone resorption was detected in the clinically relevant buccal region in the ARP group. The median bone reduction was 1.18 mm in the ARP group and 5.06 mm in the control group (=0.03).
Conclusions: The proposed hypothesis that inserting a combination material comprising a collagen cone and membrane would lead to a difference in alveolar bone preservation can be accepted for the clinically relevant buccal distance. In this area, implantation of the collagen material led to significantly less alveolar bone resorption. German Clinical Trials Register at www.drks.de, DRKS00004769.
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http://dx.doi.org/10.5051/jpis.2018.48.4.236 | DOI Listing |
BMC Oral Health
December 2024
College of Dental Medicine, QU Health, Qatar University, P.O. Box: 2713, Doha, Qatar.
Background: The collum angle, tooth dimensions, root length, and alveolar bone thickness have a significant impact on orthodontic diagnosis and treatment planning. The boundaries of orthodontic tooth movement are determined by alveolar bone thickness and dimensions while the collum angle determines the appropriate positioning of the root relative to the cortical plate. This study aimed to compare the collum angle, crown dimensions, root length, and alveolar bone thickness of the upper and lower incisors, canines, and premolars in subjects with varying anteroposterior relationships.
View Article and Find Full Text PDFBMC Oral Health
December 2024
Department of Orthodontics, Central Laboratory, Hospital for Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School, 22th Zhongguancun South Ave, Beijing, 100081, China.
Background: Orthodontic tooth movement (OTM) relies on the remodeling of periodontal tissues, including the periodontal ligament (PDL) and alveolar bone. Collagen remodeling plays a crucial role during this process, allowing for the necessary changes in the PDL's structure and function. Endo180, an urokinase plasminogen activator receptor-associated protein, is a transmembrane receptor regulated collagen remodeling.
View Article and Find Full Text PDFPeriodontol 2000
December 2024
Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Periodontitis arises from imbalanced host-microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro-inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment. There is no consensus on the factors that lead to a conversion from gingivitis to periodontitis, but one possibility is the proximity of the inflammation to the bone, which promotes bone resorption and inhibits subsequent bone formation during coupled bone formation.
View Article and Find Full Text PDFClin Oral Investig
December 2024
Department of Stomatology, First Branch Hospital of First Affilliated Hospital, Chongqing Medical University, Chongqing, China.
Objectives: The aim of this study was evaluate the effect of Platelet-Rich Fibrin (PRF) in patients after mandibular third molar extraction through an analysis of the most current literature on systematic reviews and meta-analyses.
Data, Sources And Study Selection: By using computer-assisted search technology, we comprehensively searched several reliable databases, such as China National Knowledge Infrastructure (CNKI), WanFang Data, the Chinese biomedical literature database, PubMed, Web of Science, EMBase, and the Cochrane Library, and performed a systematic retrospective meta-analysis on all of the collected studies on the therapeutic effects of PRF on patients after mandibular third molar extraction. A total of nine meta-analyses were performed in this study, and all nine studies were rated as high quality on the basis of the AMSTAR 2 criteria.
J Transl Med
December 2024
Department of General Surgery and Surgical-Medical Specialties, Unit of Periodontology, School of Dentistry, University of Catania, Via S. Sofia 78, Catania, Catania, 95123, Italy.
Background: Micro-RNAs (miRNAs) have been reported to play an important role during orthodontic tooth movement (OTM) through the regulation of periodontal soft and hard tissue homeostasis and functions. The aim of the present study was to assess the effects of miRNAs on OTM and to evaluate possible predictors that influenced the overall OTM amount at a 3-month follow-up.
Methods: Through a split-mouth design, 21 healthy patients (mean age 13.
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