Damage identification that is based on modal analysis is widely used in traditional structural damage identification. However, modal analysis is difficult in high damping structures and modal concentrated structures. Unlike approaches based on modal analysis, damage identification based on the frequency response function allows for the avoidance of error and easy verification through other test points. An updating algorithm is devised is this study by utilizing the frequency response function together with the dynamic reduction with respect to the selected design parameters. Numerical results indicate that the method can be used to define multiple parameters with large variation and incomplete measurement data and is robust against measurement noise. With the purpose of avoiding the occurrence of resonance and gaining additional information, the trial and error method has been used to choose a proper frequency. Furthermore, an experimental scale model in a soil box is subjected to the excitation of moving load to validate the effectiveness of the damage identification approach. The improved damage identification method for underground structures, which is based on the analysis of the frequency response function, can be adopted as an efficient and functional damage identification tool.
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http://dx.doi.org/10.3390/s18093033 | DOI Listing |
BMC Genomics
January 2025
College of Life Sciences, Shaanxi Normal University, Xi'an, 710062, China.
Background: Chemosensory perception plays a vital role in insect survival and adaptability, driving essential behaviours such as navigation, mate identification, and food location. This sensory process is governed by diverse gene families, including odorant-binding proteins (OBPs), olfactory receptors (ORs), ionotropic receptors (IRs), chemosensory proteins (CSPs), gustatory receptors (GRs), and sensory neuron membrane proteins (SNMPs). The oriental mole cricket (Gryllotalpa orientalis Burmeister), an invasive pest with an underground, phyllophagous lifestyle, causes substantial crop damage.
View Article and Find Full Text PDFNat Biotechnol
January 2025
Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.
Efficient and accurate nanocarrier development for targeted drug delivery is hindered by a lack of methods to analyze its cell-level biodistribution across whole organisms. Here we present Single Cell Precision Nanocarrier Identification (SCP-Nano), an integrated experimental and deep learning pipeline to comprehensively quantify the targeting of nanocarriers throughout the whole mouse body at single-cell resolution. SCP-Nano reveals the tissue distribution patterns of lipid nanoparticles (LNPs) after different injection routes at doses as low as 0.
View Article and Find Full Text PDFDis Mon
January 2025
Department of Pediatric and Adolescent Medicine, Western Michigan University, Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA.
The subject of substance use disorders in the pediatric population remains a disturbing conundrum for clinicians, researchers and society in general. Many of our youth are at risk of being damaged and even killed by drug addictions that result from the collision of rapidly developing as well as vulnerable central nervous systems encountering the current global drug addiction crisis. A major motif of this chemical calamity is opioid use disorder in adolescents and young adults that was stimulated by the 19th century identification of such highly addictive drugs as morphine, heroin and a non-opiate, cocaine.
View Article and Find Full Text PDFMedicine (Baltimore)
November 2024
Yantai Yuhuangding Hospital, Shandong, China.
Background: The neutrophil-mediated generation of neutrophil extracellular traps (NETs) results in an augmented inflammatory response and cellular tissue injury during acute myocardial infarction (AMI). Through the analysis of public database information, we discovered and confirmed putative critical genes involved in NETs-mediated AMI.
Methods: The AMI dataset GSE66360 and the single-cell dataset GSE163465 were downloaded from the Gene Expression Omnibus database.
Eur J Med Chem
January 2025
Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Shanghai Integration and Innovation Center of Marine Medical Engineering, China. Electronic address:
The identification of novel molecular candidates capable of treating osteoarthritis (OA) has significant clinical implications. Monocyte locomotion inhibitory factor peptide (MLIF) is a pentapeptide derived from Entamoeba histolytica. It has been found possesses selective anti-inflammatory effects both in vitro and in vivo.
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