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Thermal ablation of solid tumors via focused ultrasound (FUS) is a non-invasive image-guided alternative to conventional surgical resection. However, the usefulness of the technique is limited in vascularized organs because of convection of heat, resulting in long sonication times and unpredictable thermal lesion formation. Acoustic cavitation has been found to enhance heating but requires use of exogenous nuclei and sufficient acoustic monitoring. In this study, we employed phase-shift nanoemulsions (PSNEs) to promote cavitation and incorporated passive acoustic mapping (PAM) alongside conventional magnetic resonance imaging (MRI) thermometry within the bore of a clinical MRI scanner. Simultaneous PAM and MRI thermometry were performed in an in vivo rabbit tumor model, with and without PSNE to promote cavitation. Vaporization and cavitation of the nanoemulsion could be detected using PAM, which led to accelerated heating, monitored with MRI thermometry. The maximum heating assessed from MRI was well correlated with the integrated acoustic emissions, illustrating cavitation-enhanced heating. Examination of tissue revealed thermal lesions that were larger in the presence of PSNE, in agreement with the thermometry data. Using fixed exposure conditions over 94 sonications in multiple animals revealed an increase in the mean amplitude of acoustic emissions and resulting temperature rise, but with significant variability between sonications, further illustrating the need for real-time monitoring. The results indicate the utility of combined PAM and MRI for monitoring of tumor ablation and provide further evidence for the ability of PSNEs to promote cavitation-enhanced lesioning.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215518 | PMC |
http://dx.doi.org/10.1016/j.ultrasmedbio.2018.07.023 | DOI Listing |
Diagn Interv Imaging
December 2024
Univ. Bordeaux, CNRS, CRMSB, UMR 5536, IHU Liryc, 33000 Bordeaux, France.
Purpose: The primary purpose of this study was to evaluate the accuracy of an MR-thermometry sequence for monitoring prostate temperature. The secondary purposes were to analyze clinical and technical factors that may affect accuracy and testing the method in a realistic setting, with MR-guided Laser ablation on an ex vivo muscle sample.
Materials And Methods: An ex vivo muscle sample was subjected to Laser ablation while using a two-dimensional multislice segmented echo planar imaging sequence for MR thermometry.
Ultrasound Med Biol
February 2025
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address:
Objective: Transcranial magnetic resonance imaging (MRI)-guided histotripsy has been demonstrated to treat various locations in in vivo swine brain through a human skull. To ensure that the histotripsy treatment is delivered to the intended target location, accurate pre-treatment targeting is necessary. In this work, we investigate the feasibility of MR-thermometry and MR-acoustic radiation force imaging (MR-ARFI) to perform pre-treatment targeting of histotripsy in ex vivo bovine brain through a human skull.
View Article and Find Full Text PDFMed Phys
November 2024
CNRS, CRMSB, UMR 5536, IHU Liryc, University of Bordeaux, Bordeaux, France.
Background: Quantitative real-time MRI-based temperature mapping techniques are hampered by abdominal motion. Intrascan motion can be reduced by rapid acquisition sequences such as 2D echo planar imaging (EPI), and inter-scan organ displacement can be compensated by image processing such as optical flow (OF) algorithms. However, motion field estimation can be seriously affected by local variation of signal intensity on magnitude images inherent to tissue heating, potentially leading to erroneous temperature estimates.
View Article and Find Full Text PDFComput Biol Med
January 2025
University of Bordeaux, CNRS, CRMSB, UMR 5536, IHU Liryc, Bordeaux, France.
Background: Clinical Laser-Induced Thermotherapy (LITT) currently lacks precise control of tissue temperature increase during the procedure. This study presents a new method to automatically regulate the maximum temperature increase in vivo at different positions by adjusting LITT power delivered by multiple laser probes using real-time volumetric MR-thermometry.
Methods: The regulation algorithm was evaluated in vivo on a pig leg muscle.
Magn Reson Med
November 2024
The xMR Labs, Department of Physics and Astronomy, Western University, London, Ontario, Canada.
Purpose: Evaluate the use of both single-echo gradient recalled echo (SE-GRE) and EPI approaches to creating temperature maps on a mid-field head-only scanner, both in vivo and on a tissue mimicking gel.
Methods: Three 2D protocols were investigated (an SE-GRE, single-shot EPI, and an averaged single-shot EPI). The protocols used either a gradient recalled acquisition or an echo planar acquisition, with EPI parameters optimized for the longer at lower field-strengths.
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