[Secondary metabolites of Streptomyces sp. A1693].

Zhongguo Zhong Yao Za Zhi

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Published: August 2018

AI Article Synopsis

  • Ten compounds were isolated from the bacteria Streptomyces sp. A1693 using various chromatographic techniques, including Sephadex LH-20 and HPLC.
  • Their structures were determined through spectroscopic data and physical methods, revealing 5 butenolides, 2 diketopiperazines, and 3 antimycin antibiotics.
  • Compound 1 was identified as a new compound, and none of the isolated compounds exhibited cytotoxic activity against the A549 cell line, indicating an IC₅₀ value greater than 50 mg·L⁻¹.

Article Abstract

By means of various chromatographic methods such as Sephadex LH-20,ODS,and semi-preparative HPLC,ten compounds were isolated from Streptomyces sp. A1693 and their structures were elucidated on the basis of spectroscopic data and physico-chemical methods. The compounds comprised 5 butenolides,2 diketopiperazines,and 3 antimycin antibiotics. The structures were identified as (5)-5-(11-hydroxymethyloctyl)furan-2(5)-one (1), (5)-5-(11-hydroxy-11-methylheptyl)furan-2(5)-one (2), (5)-5-(11-methyl-12-oxooctyl) furan-2(5)-one (3), (5)-5-(11-hydroxy-11-methyloctyl)furan-2(5)-one (4), (5)-5-(11-hydroxy-12-methyloctyl)furan-2(5)-one(5),cyclo-Phe-Val (6),cyclo-Phe-Ile (7),uranchimycin A (8),uranchimycin B (9),and deisovalerylblastomycin (10). Among them,1 was defined as a new compound. All the compounds didn't show the cytotoxic activity against A549 cell line (IC₅₀>50 mg·L⁻¹).

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180510.008DOI Listing

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