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Skin microbiome and polymorphous light eruption.

Br J Dermatol

December 2024

Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria.

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  • Paraneoplastic pemphigus (PNP) is a rare autoimmune blistering disease linked to cancer, typically presenting with severe mouth sores and varied skin eruptions.
  • The case study details a patient with follicular lymphoma (FL) who developed symptoms of PNP, prompting a review of current treatment options and understanding of the disease.
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  • Ferroptosis is a unique type of regulated cell death that differs from apoptosis, necrosis, and autophagy, and is gaining attention for its involvement in skin diseases.
  • The review explores how ferroptosis, characterized by iron buildup and lipid damage, affects several skin conditions like psoriasis, dermatitis, and melanoma, while also comparing it to other cell death processes.
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  • Photoallergic contact dermatitis (PACD) is a hypersensitivity reaction triggered by allergens only when exposed to UV light, requiring photopatch testing (PhotoPT) for diagnosis.* -
  • A study from 2009-2020 involving 454 patients revealed that most were women, aged 21-60, and the majority were White; results showed 119 positive tests, predominantly related to sunscreen agents like benzophenones.* -
  • Among the diagnosed conditions, approximately 17.2% of patients had PACD, while other diagnoses included allergic contact dermatitis, polymorphous light eruption, and chronic actinic dermatitis, highlighting the need for photopatch testing in these cases.*
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